The orthodontic treatment is most favorable and effective during growth and hence the assessment of growth is significant in treatment planning for dental and maxillofacial malocclusion [1,2]. Several features such as body height, weight and sexual characteristics, dental and skeletal development are used to evaluate the pubertal growth. The stage of tooth maturation can determine the dental ma...

The molar tooth of the crayfish Cherax quadricarinatus is part of the mandible, and is covered by a layer of apatite (calcium phosphate). This tooth sheds and is regenerated during each molting cycle together with the rest of the exoskeleton. We discovered that molar calcification occurs at the pre-molt stage, unlike calcification of the rest of the new exoskeleton. We further identified a nove...

In the developing tooth, 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) causes hypoplasia and hypomineralization of enamel and dentine. The present study was undertaken to clarify the effects of HEBP on the formation of dental tissues of tooth germs in an organ culture system. Mandibular first molars from 17.5-day-old mouse embryos were cultured with or without 250 microM HEBP in culture medium....

In previous studies by our group, we reported that thymosin beta 4 (Tb4) is closely associated with the initiation and development of the tooth germ, and can induce the expression of runt-related transcription factor 2 (RUNX2) during the development of the tooth germ. RUNX2 regulates the expression of odontogenesis-related genes, such as amelogenin, X-linked (Amelx), ameloblastin (Ambn) and ena...

Background: Using a reliable indicator to identify different phases of skeletal maturation is an important issue in orthodontic diagnosis and treatment planning. Objectives: The aim of this study was to evaluate the correlation between stages of tooth calcification and cervical vertebral maturation in Iranian individuals. Patients and Methods: 216 digital panoramic and lateral cephalometry of h...

This case report describes a rare case of an adenomatoid odontogenic tumor (AOT) arising in the mandibular third molar region of a 20-year-old female. The tumor was a well-circumscribed intraosseous lesion with an embedded tooth. Histologically, the induction of extensive globular calcification was evident in addition to the characteristic histological features of AOT. The present case lends su...

OBJECTIVE Radiographic evaluation of the third molar tooth to determine its position and degree of development is an important part in diagnosis and treatment planning, as well as in forensic dentistry procedures. The objective was to investigate the developmental stages of third molars in relation to chronologic age, gender and location (maxillary/mandibular) in an Iranian population. MATERI...

Keratan sulfate proteoglycan and dermatan sulfate proteoglycan have been reported to inhibit collagen fibrillogenesis. We investigated their distribution in order to evaluate the role of proteoglycan in dentinogenesis. Specimens of porcine tooth-germ dentin and erupted teeth were the materials on which antibodies to keratin sulfate and dermatan sulfate proteoglycan were used. Predentin was foun...

BACKGROUND Considerable variations in the development stage among patients of the same chronological age have led to introduce the concept of the developmental age based on the maturation of different organs such as cervical vertebrae or teeth. OBJECTIVES The purpose of this study was to investigate the correlation between the stages of tooth calcification and the cervical vertebral maturatio...