The effects of eucalyptol were evaluated against the house fly, Musca domestica L., and blow fly, Chrysomya megacephala (F.). The bioassay of adults, using topical application, indicated that M. domestica males were more susceptible than females, with the LD50 being 118 and 177 microg/fly, respectively. A higher LD50 of C. megacephala was obtained; 197 microg/fly for males and 221 microg/fly fo...

BACKGROUND The efficacy of essential oil of Chenopodium ambrosioides flowering aerial parts and its three main active ingredients was evaluated against Blattella germanica male adults. METHODS Composition of essential oil was determined by GC-MS. Topical application bioassay was used to evaluate contact toxicity of essential oil and three main components. Fumigant toxicity of essential oil an...

Topical treatment of severe ocular infections may require the use of antibiotics fortified in concentration beyond commercially available preparations. The authors studied tear pharmacokinetics, tissue bioavailability, epithelial toxicity, and comparative antibacterial efficacy of topical tobramycin concentrations ranging from 0.3-5.0%. Tear pharmacodynamics demonstrate bioassay-measurable leve...

The toxicities of two new insecticides, hydramet.hylnon and abamectin, were evaluated against one susceptible and seven insecticide-resistant strains of 81attella gennanica. (L.) Both materials proved to be potent insecticides against the susceptible strain. There was no difference in toxicity, based on LTfoO values, of hydramethylnon between resistant and susceptible strains in a feeding bioas...

Dose assessment after intakes of radionuclides requires application of biokinetic and dosimetric models and assumptions about factors influencing the final result. In 2006, a document giving guidance for such assessment was published, commonly referred to as the IDEAS Guidelines. Following its publication, a working group within the European networks CONRAD and EURADOS was established to improv...

Bioassays can be used to estimate the initial intake I for the case of an acute intake exposure for an individual worker. To evaluate the effective dose, apart from I, we need to know other parameters such as activity median aerodynamic diameter (AMAD) or the fraction absorption ( f(1)) in the blood from the GI tract, but in an accident situation these parameters are often unknown. The bioassay...

We studied the mechanism of the vasodilator effect of H2O2 on cerebral arterioles and its effect on endothelium-dependent responses to acetylcholine. Topical application of H2O2 (0.1-1 fiM) on the brain surface of anesthetized cats equipped with cranial windows induced dosedependent arteriolar dilation, which was markedly inhibited by topical deferoxamine, showing that it was probably mediated ...

the purpose of the present study was to determine the acute toxicity (lc 50 ) of hgcl 2 and cuso 4 in caspian roach ( rutilus caspicus ) and cuso 4 in caspian kutum ( rutilus kutum ). the caspian roach lc 50 values for hgcl 2 at 24, 48, 72, and 96-hrs of exposure, were 0.64, 0.61, 0.42, and 0.28 mg l -1 , respectively, and for cuso 4 were 11.55, 5.08, 2.49, and 1.47 mg l -1 , respectively. the ...

We studied the mechanism of the vasodilator effect of H2O2 on cerebral arterioles and its effect on endothelium-dependent responses to acetylcholine. Topical application of H2O2 (0.1-1 microM) on the brain surface of anesthetized cats equipped with cranial windows induced dose-dependent arteriolar dilation, which was markedly inhibited by topical deferoxamine, showing that it was probably media...