Teratogenic and toxicological effects of lidocaine administered during pregnancy were evaluated in the Sprague Dawley rat. High doses of lidocaine administered during specific periods of gestation were shown to produce no apparent adverse toxicological or teratogenic effects. Histological, enzymological, and physical features of the fetuses, utilizing conventional toxicological parameters, were...

1 Department of Clinical and Toxicological Analysis, University of Alfenas-MG, Av. Gabriel Monteiro da Silva, 714, Alfenas, MG, Brazil, 37130.000 2 Laboratory of Industrial Hygiene and Toxicology, University of Brescia, P.le Spedali Civili, 1, 25100, Brescia, Italy 3 Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Lineu Prestes...

background: this toxicological investigation involves a report on the death of four ‎occupants of a sport utility vehicle on one of the major busy federal roads of nigeria ‎where they were held for up to three hours in a traffic jam while the car was steaming.‎ methods: autopsy was executed using the standard procedure and toxicological ‎analysis was done using simple spectrophotometric method ...

This brief sketch is intended as an introduction to a series of articles 1 on bioelectrical phenomena, its purpose being to present certain fundamental facts and underlying conceptions. Early in the course of the investigation it became evident that there are great advantages in using single cells in place of tissues. The experiments were accordingly made with single (multinucleate) cells of Va...

An attempt was made to evaluate the selectivity of PDA UV spectra for systematic toxicological analysis (STA). A great spectral variety was found among compounds of toxicological interest. With modern generation PDA detectors even compounds of high structural similarity can be successfully distinguished down to a LOI as low as 10 ng/ml.

Objective: Cannabis use is considered a major clinical problem associated with a poorer outcome in patients with schizophrenia. The objective of the present study was to assess the prevalence of cannabis us among patients with schizophrenia. The assessment consists in comparing some factors related to substance use in a population of schizophrenic patients between cannabis user...

An automated full-range quantitation method for identifying d-methamphetamine (d-MA) in human hair using a microchip-based ELISA system (microELISA) in combination with a micropulverized extraction method for sample preparation has been developed. An anti-d-MA antibody and a peroxidase-linked MA were used for the competitive ELISA assay. Method validation was carried out using doped hair sample...