Key words: aircraft de-icing fluid (ADF), phytoremediation, tolyltriazole, propylene glycol, ethylene glycol Aircraft de-icer fluids (ADFs) and antifreeze solutions are mainly formulations of either propylene or ethylene glycol and additives such as benzotriazole methyl substitution isomers (tolyltriazoles), and surfac-tants. Although the formulations are proprietary, in general the glycols are...

1,2,3-triazoles are important scaffolds in several fields, and there is still a demand to construct these compounds, most notably the disubstituted 4, 5 compounds. The latter obtained different ways, but 4- 5-halo triazoles generally key intermediates their synthesis. These halogenated compounds an extraordinary platform leading great chemical diversity around 4 positions. However, own pathways...

There has been an increase in the number of patients susceptible to invasive fungal infections (IFIs) leading to a greater need for effective, well tolerated, and easily administered antifungal agents. The advent of triazoles has revolutionized the care of patients requiring treatment or prophylaxis for IFIs. However, triazoles have been associated with a number of adverse events and significan...

In the last few years, nonsteroidal aromatase inhibitors (AIs) have been emerged as promising agents for treating hormone-dependent breast cancer in postmenopausal women because of their inhibitory effect on estrogen synthesis. Indeed, these compounds can block activity aromatase, enzyme that intervenes steps production pathway. Triazoles are core structures AIs. The nitrogen atom triazole moie...

The highly controversial force-induced cycloreversion of 1,2,3-triazole, its well-known retro-click reaction, is shown to be possible only for 1,5-substituted triazoles, but competes with rupture of an adjacent singlebond. We draw this conclusion from both static and dynamic calculations under external mechanical forces applied to unsubstituted and 1,4and 1,5-substituted triazoles. The JEDI (Ju...

Regioselective syntheses of 1,4,5-trisubstituted 1,2,3-triazoles were accomplished by three different strategies, relying on (i) the interception of stoichiometrically formed 5-cuprated-1,2,3-triazoles, (ii) the use of stoichiometrically functionalized alkynes or (iii) catalytic C-H bond functionalizations. This perspective article summarizes progress in this research area until June 2010.

Allene triazole derivatives were successfully synthesized for the first time through iron catalyzed regioselective triazole addition to tertiary propargyl alcohols. The reaction proceeds under mild conditions, giving the desired allene-triazoles in good to excellent yields (up to 96%). The resulting allene-triazoles were confirmed by X-ray crystallography and indicated improved stability.

Propargylamines are popular substrates for triazole formation, but tetrasubstituted variants have required multistep syntheses involving stoichiometric amounts of metal. A recent cyclohexanone-amine-silylacetylene coupling forms silyl-protected tetrasubstituted propargylamines in a single copper-catalyzed step. The development of the tandem silyl deprotection-triazole formation reported herein ...

Triazoles and its derivatives possess a great importance in medicinal chemistry and can be used for the synthesis of numerous heterocyclic compounds with different biological activities. This review article covers the latest information over active triazoles derivatives having different pharmacological action such as, antiviral, antibacterial, antifungal and antituberculosis. Thus triazole acts...