Abstract Triclabendazole is one of the main drugs used to treat liver fluke in livestock. A rapid LC-MS/MS method was developed and validated determine ovine plasma levels triclabendazole sulfoxide. Gemini NX-C18 column achieve analytical separation, with gradient elution a mobile phase composed 0.1% formic acid acetonitril water at flow rate 0.6 mL/min. MRM positive ESI ionization for detectio...

Control of fasciolosis is threatened by the development of anthelmintic resistance. Enhanced triclabendazole (TCBZ) efflux by ABC transporters such as P-glycoprotein (Pgp) has been implicated in this process. A putative full length cDNA coding for a Pgp expressed in adult Fasciola hepatica has been constructed and used to design a primer set capable of amplifying a region encoding part of the s...

ABCG2/BCRP is an ATP-binding cassette transporter that extrudes compounds from cells in the intestine, liver, kidney, and other organs, such as the mammary gland, affecting pharmacokinetics and milk secretion of antibiotics, anticancer drugs, and other compounds and mediating drug-drug interactions. In addition, ABCG2 expression in cancer cells may directly cause resistance by active efflux of ...

A total of 24 drugs were evaluated as regards their efficacy for oral treatment of gyrodactylosis in rainbow trout Oncorhynchus mykiss. In preliminary trials, all drugs were supplied to infected fish at 40 g per kg of feed for 10 d. Twenty-two of the drugs tested (aminosidine, amprolium, benznidazole, bithionol, chloroquine, diethylcarbamazine, flubendazole, levamisole, mebendazole, metronidazo...

INTRODUCTION We aimed to analyze the approaches to the diagnosis and treatment of patients with fascioliasis in light of current literature. METHODOLOGY Thirty-nine patients with fascioliasis admitted to the Surgery Clinic of Dicle Medical Faculty (Turkey) were included in this study. The demographic, clinical, diagnostic, treatment and outcome data were analyzed retrospectively. RESULTS Ab...

background: aspartate transaminase (ast) is an important enzyme in parasite and liver tissue. the purpose of this investigation is to evaluate triclabendazole (tcbz) effect on ast activity of fasciola gigantica parasite. to compare of enzyme level of parasite and its host tissue, enzyme activity of f. gigantica parasite and liver tissues were also determined. method: the livers were collected f...

hydatid disease is a term used to refer infection with the methacestode of echinococcus granulosus parasite in humans, and echinococcusis is restricted to infection with the adult stage in carnivores.glutathione s-transferase (gst) represents the major class of detoxification enzymes from helminth parasites such as echinococcus protoscoleces (psc) and it is candidate for chemotherapeutic and va...

Fascioliasis, a zoonotic disease of domestic herbivorous animals such as sheep, cattle and goats, which are the definitive hosts, is caused by infection with the liver fluke, Fasciola hepatica. Humans become infected by eating uncooked, and usually unwashed, aquatic vegetables on which larval parasites are encysted. Although animals can support enormous worm burdens without developing serious d...