The ability of a number of prostaglandin F 2 alpha (PGF 2 alpha) analogs to mobilize intracellular Ca2+[Ca2+]iand to compete for [3H]PGF 2 alpha binding to prostaglandin F 2 alpha receptors (FP) was evaluated. Radioligand binding studies measuring displacement of [3H]PGF 2 alpha by a variety of FP prostaglandin analogs yielded the following rank order of affinities: travoprost acid [(+)-16-m-tr...

one of the most important questions in islamic banking system is about the best method for calculating the interest rate of loans and deposits. this paper compares two methods : time- value method and economic value- added method and tries to answer this question that, based on the information gathered from the financial statements of a sample of the accepted firms in the iranian exchange marke...

Prostaglandin E2 (PGE2) is an endogenous hormone of adrenal zona glomerulosa cells and is released in response to stimulation by agonists such as angiotensin II (Ang II). It stimulates the release of aldosterone from cultured bovine adrenal zona glomerulosa cells. These studies were designed to determine whether this steroidogenic effect of PGE2 was mediated by an EP1, EP2, or EP3 receptor. Pro...

17-Trifluoromethyl phenyl trinor prostaglandin F2? (17-TPGF2?) is extracted from a Zinc database, but its value for inhibiting breast cancer (BC) through the substance P (SP)/NK1R system remains unknown. This study was designed to investigate potential antagonist effect of 17-TPGF2? neurokinin 1 receptor (NK1R). The on proliferation and apoptosis BC cell lines determined in vitro lines. Based r...

Nonsteroidal anti-inflammatory drugs (NSAIDs) are antitumorigenic in humans as well as in animal models of intestinal neoplasia, such as the adenomatous polyposis coli Min/ (Apc ) mouse. NSAIDs inhibit cyclooxygenase (COX) isozymes, which are responsible for the committed step in prostaglandin biosynthesis, and this has been considered the primary mechanism by which NSAIDs exert their antitumor...

A kinetic model is presented that explains the more than thirty-fold enrichment of atomic nitrogen component with 15 N isotope in post-discharge zone. Isotopic due to activation nature exchange reaction atoms vibrationally excited molecules, upper vibrational levels which are enriched molecules containing a heavier during non-equilibrium vibrational-vibrational exchange. The dependences concent...

We evaluated the effectiveness of latanoprost (Xalatan) monotherapy in primary open angle glaucoma (POAG). Latanoprost is a prostaglandin analogue, the pure 15(R) epimer of 13,14-dihydro-17-phenyl-18,19,20-trinor-PGF2alpha-isopropyl ester. As a prodrug it is being activated by enzymatic hydrolysis in the cornea after which it becomes active acid of latanoprost. Latanoprost is lowering the intra...