BACKGROUND Oral tacrolimus therapy is effective for refractory ulcerative colitis (UC), but dose adjustment according to the trough concentrations which varies largely among individuals, is required. This study aimed to identify factors to predict the tacrolimus dose required for achieving the target trough level for remission induction of UC. METHODS Forty-seven consecutive UC patients who w...

In the present work the efficiency of a solar parabolic trough has been investigated experimentality. parabolic trough solar collector constitute a proven source of thermal energy for industrial process heat and power genaration. The impact of  using the partially porous media in the absorber on the efficiency of PTC (parabolic trough collector) has been investigated. The porosity of copper foa...

Continued increases in Johne’s disease around the world suggest more information is needed to understand the mechanisms by which the causative agent, Mycobacterium avium subsp paratuberculosis (MAP), is spread among livestock on the farm site. Livestock watering troughs are frequented by all animals on a farm; they provide a moist, nutrient-rich environment for bacterial survival, and the troug...

OBJECTIVES The aim of this study was to determine the incidence of toxic trough serum gentamicin levels in neonates in the first week of life, with different dosage intervals. METHODS This was a retrospective study of neonates born between 01.07.95 and 31.12.95, who received gentamicin. Data were collected on birth weight, gestation, gentamicin dose, the trough level of gentamicin, serum crea...

OBJECTIVES The incidence of methicillin-resistant Staphylococcus aureus (MRSA) infections in intensive care units in Malaysia is significant. Invasive MRSA infections are commonly treated with vancomycin. In clinical practice, the serum vancomycin trough concentration is used as a surrogate marker of vancomycin efficacy. A low concentration of vancomycin may result in less effective therapy and...

OBJECTIVE To describe the relationships between dosing strategy, age, and vancomycin trough concentrations in pediatric patients. METHODS This is a retrospective review of hospitalized pediatric patients between 2 months and 17 years of age treated with intravenous vancomycin from 2008 to 2011. The primary outcome was the number of patients achieving a target trough concentration of 10 to 20 ...

Objective: This study aimed to assess whether currently used dosages of vancomycin for treatment of serious gram-positive bacterial infections in intensive care unit patients provided initial therapeutic vancomycin trough levels and to examine possible factors associated with the presence of adequate initial vancomycin trough levels in these patients. Methods: A prospective descriptive study ...

The ionospheric mid-latitude trough minimum position as a function of geomagnetic storm time is identified and investigated statistically in terms of the category and the intensity of storms. The data of ion density derived from DMSP and DEMETER satellites were used to extract the trough position. The variations of mid-latitude trough in 41 moderate magnetic storms and 88 intense magnetic storm...

[1] We use simultaneous global observations of the mid-latitude trough and the plasmapause to experimentally prove a long-standing conjecture of magnetosphereionosphere couplingnamely the mid-latitude trough and plasmapause are on the same field line. Global Ionospheric Maps (GIM), generated using ground based GPS receivers, are used to detect the globally extended mid-latitude trough; while gl...