The basement membrane plays an important role in maintaining the structural and functional integrity of tissues. Altered basement membrane structure has been associated with severe functional impairment of the testis in several conditions, including vasectomy, autoimmune orchitis, cryptorchidism, and following x-irradiation. We have used efferent duct ligation as a model to examine seminiferous...

conclusions the ligation method with attention to the modifications described further in the article is a simple, safe and cost effective option for the management of urethral prolapse.rnmaintaining the inflated balloon of the foley catheter with timed catheter removal especially adds predictability to this technique. results the mean age of the patients was 6 years old (ranging from 3 to 8 yea...

Background: Tubal ligation is one of the most common contraceptive methods in the world. Some researchers believe that tubal ligation has complications. It is assumed oxidative stress can produce these complications. The aim of this study was to evaluate oxidative stress and ovarian function after tubal ligation. Materials and Methods: In this study, female rats (weighting 200-250 g) were divid...

objective: despite development of new contraceptive methods, sterilization remained the most widely used method. our objective was to determine the factors contributing to decision making for tubal ligation in females. materials and methods: a cross sectional study was conducted in jinnah post graduate medical centre (jpmc) between march - november 2008. about 505 females using contraceptive me...

Hughes, Jeremy, and Richard J. Johnson. Role of Fas (CD95) in tubulointerstitial disease induced by unilateral ureteric obstruction. Am. J. Physiol. 277 (Renal Physiol. 46): F26–F32, 1999.—Murine renal tubular epithelial cells and interstitial fibroblasts may express both Fas (CD95) death receptor and Fas ligand and are vulnerable to Fas-mediated death in vitro. We therefore hypothesized that a...

Unilateral ureteral obstruction (UUO) results in a number of pathophysiological and morphological changes in the renal parenchyma, including interstitial inflammation and fibrosis, apoptotic changes of tubular and interstitial cells. Recent studies have indicated an association between renin-angiotensin system and apoptotic alterations in the kidney after unilateral obstructive nephropathy. In ...

Toll-like receptors (TLRs) are now recognized as the major receptors for microbial pathogens on cells of the innate immune system. Recently, TLRs were also identified in many organs including the kidney. However, the cellular distribution and role of these renal TLRs remain largely unknown. In this paper, we investigated the expression of TLR4 in a cecal ligation and puncture (CLP) model of sep...

Asiatic acid (AA) is one of the triterpenoid compounds present in Centella asiatica and it has been shown to be capable of attenuating liver fibrosis. In the present study, we investigated the effects of AA on renal tubulointerstitial fibrosis in mice with unilateral ureteral obstruction (UUO). Mice were divided randomly into five groups (n=5 per group): the sham-surgery (Sh), UUO plus vehicle ...

Adrenocorticotropic hormone (ACTH) has a renoprotective effect in chronic kidney disease; however, its effect on acute kidney injury (AKI) remains unknown. In a rat model of tumor necrosis factor (TNF)-induced AKI, we found that ACTH gel prevented kidney injury, corrected acute renal dysfunction, and improved survival. Morphologically, ACTH gel ameliorated TNF-induced acute tubular necrosis, as...

Acute kidney injury (AKI) is a rapid loss of kidney function characterized by damage to renal tubular cells driven by mitochondrial dysregulation and oxidative stress. Here, we used a murine caecal ligation and puncture (CLP) model of sepsis-induced AKI to study the role of sirtuin 3 (SIRT3), a NAD(+) dependent deacetylase critical for the maintenance of mitochondrial viability, in AKI-related ...