purpose: to report five cases of wolfram syndrome, an autosomal recessive neurodegenerative disease with ِdiabetes insipidus, diabetes mellitus, optic atrophy, and deafness (didmoad syndrome). patients and findings: all of the five patients had diabetes mellitus and optic atrophy. four patients had hearing loss. in spite of persistence of polyuria and polydipsia, diabetes insipidus had been prev...

diabetes mellitus is a multifactorial disease. it has recently been shown that an insertion (i)/deletion (d) polymorphism exists in the angiotensin-converting enzyme (ace) gene that can affect the serum ace level. there are three genotypes: dd, di, and ii, with the ace level being highest in dd, intermediate in di, and lowest in ii. in the present investigation, 170 patients with type 2 diabete...

conclusions our study showed a significant association between h63d and c282y mutations and the risk of type 2 diabetes in iranian population. background type 2 diabetes (t2d) is a common metabolic disease caused by insulin secretion defects, which is associated with a variety of complications such as retinopathy, nephropathy, and neuropathy. objectives regarding the relationship between type 2...

The association of celiac disease and type I diabetes mellitus has been known for some time. This study was undertaken to investigate the prevalence of celiac disease (CD) in diabetic children and adolescents. Eighty-seven patients (44 females, 43 males) aged 2- 18 years, with type I diabetes participated in this study. A group of 87 healthy unrelated girls and boys matched for age and gend...

aim : to determine the prevalence of gastrointestinal symptoms and signs among persons with diabetes mellitus in a specialist hospital. background : gastrointestinal symptoms and signs are common among patients with diabetes mellitus. morbidity from patients and methods : in this descriptive, cross-sectional study, subjects from the general population with diabetes (n=200) were recruited for th...

antibodies directed against the enzyme glutamic acid decarboxylase (gad) are believed to be the main cause of destruction of pancreatic islet cells in type i (insulin dependent) diabetes mellitus. the enzyme was found both in the brain and pancreatic beta cells. although similarities in identity of gad in human and rat brain have been demonstrated, little is known about the interaction between ...

objective: the autoimmune diseases tend to coexist with diabetes mellitus type i (t1dm). the concomitance of these two types of diseases will lead to poor glycemic control beside their own complications. in this study the prevalence of thyroid disorder and celiac disease among t1dm patients in yazd, iran was evaluated. materials and methods: all the patients diagnosed as t1dm in yazd younger th...

type 2 diabetes mellitus (t2dm) is recognized as a public health problem and increasingly prevalent illness. key elements of the guideline for diabetes care are based on evidence-based medicine approach and apply for population, not individuals. however, individualized care can improve diabetes management. personalized medicine is otherwise called precision medicine tries to find better predict...

Abstract Diabetes mellitus is one of the major metabolic disorders. Diabetes is recognized for severe complications including diabetic nephropathy, neuropathy and retinopathy. Long-lasting effect of hyperglycemia results in increased oxidative stress. Oxidative stress results from an imbalance between radical-generating and radical scavenging systems. Increased oxidative stress has been shown ...

abstract diabetes mellitus is one of the major metabolic disorders. diabetes is recognized for severe complications including diabetic nephropathy, neuropathy and retinopathy. long-lasting effect of hyperglycemia results in increased oxidative stress. oxidative stress results from an imbalance between radical-generating and radical scavenging systems. increased oxidative stress has been shown t...