نتایج جستجو برای: ube2q1
تعداد نتایج: 16 فیلتر نتایج به سال:
Spinal and bulbar muscular atrophy (SBMA) is characterized by loss of motoneurons and sensory neurons, accompanied by atrophy of muscle cells. SBMA is due to an androgen receptor containing a polyglutamine tract (ARpolyQ) that misfolds and aggregates, thereby perturbing the protein quality control (PQC) system. Using SBMA AR113Q mice we analyzed proteotoxic stress-induced alterations of HSPB8-m...
We analysed the expression levels of 84 key genes involved in the regulated degradation of cellular protein by the ubiquitin-proteasome system in peripheral cells from patients with frontotemporal dementia (FTD) due to C9ORF72 and GRN mutations, as compared with sporadic FTD and age-matched controls. A SABiosciences PCR array was used to investigate the transcription profile in a discovery popu...
We construct a Left-Right symmetric model in which the number of generation is related to Grassmann variables. We introduce two sets of complex Grassmann variables (θ q , θ 2 q), (θ 1 l , θ 2 l ) and associate each variable with leftand right-handed quark and lepton fields, respectively. Expanding quark and lepton fields in powers of the Grassmann variables, we find that there are exactly three...
Hepatocellular carcinoma (HCC) invades intrahepatic vessels causing tumor thrombosis. Infrequently, there is involvement of the hepatic vein (HV) and inferior vena cava (IVC). In this review, we summarize epidemiology, classification, clinical features, management HCC with HV IVC invasion. While usually portends an overall poor survival, selected patients may be candidates for aggressive treatm...
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