PURPOSE: While modern research on coronal craniosynostosis has vastly widened our breadth of knowledge regarding treatment of the condition, the mechanism underlying the development of the deformity remains uncovered and largely uninvestigated. This study evaluates midface and skull base development in nonsyndromic unilateral coronal synostosis (UCS), focusing on zygomatic and cranial base anat...

PURPOSE: Nonsyndromic craniosynostosis (NSC) has been associated with a greater risk of neurocognitive aberrations such as learning disorders, memory and attention deficits, and visuospatial abilities. Previously, our group has performed resting-state functional MRI (fMRI) studies in patients with sagittal NSC (SSO), and has found altered functional connectivity that may underlie some of the ne...

Bilateral symmetry in vertebrates is imperfect and mild asymmetries are found in normal growth and development. However, abnormal development is often characterized by strong asymmetries. Coronal craniosynostosis, defined here as consisting of premature suture closure and a characteristic skull shape, is a complex trait. The premature fusion of the coronal suture can occur unilaterally associat...

Deformities of the cranium in patients with nonsyndromic single-suture synostosis occur because of growth restriction at fused sutures and growth over compensation at normal sutures. Traditional surgery includes ostectomies of the synostotic suture to release these restricted areas and osteotomies to enable immediate cranial remodeling. In the process of reshaping the cranium, traditional appro...

BACKGROUND The premature fusion of one cranial suture, also referred to as non-syndromic craniosynostosis, most commonly involves premature fusion of the sagittal, coronal, or metopic sutures, in that order. Population-based epidemiological studies have found that the birth prevalence of single-suture craniosynostosis is both suture- and sex-dependent. METHODS Transcriptomic data from 199 ind...

Apert syndrome (AS) is one of at least nine disorders considered members of the fibroblast growth factor receptor (FGFR) -1, -2, and -3-related craniosynostosis syndromes. Nearly 100% of individuals diagnosed with AS carry one of two neighboring mutations on Fgfr2. The cranial phenotype associated with these two mutations includes coronal suture synostosis, either unilateral (unicoronal synosto...

Boundaries between cellular compartments often serve as signaling interfaces during embryogenesis. The coronal suture is a major growth center of the skull vault and develops at a boundary between cells derived from neural crest and mesodermal origin, forming the frontal and parietal bones, respectively. Premature fusion of these bones, termed coronal synostosis, is a common human developmental...

plagiocephaly (oblique skull) is premature fusion of one of the coronal sutures. frontal plagiocephaly is a rare congenital deformity in the skull that is the most complicated form of craniosynostosis to treat. examination of all sutures is necessary for diagnosis of craniosynostosis in this article, a 10-month-old, healthy girl with deformity of the right forehead and orbit that is caused by f...