Gout is a systemic disorder characterized by hyperuricemia and recurrent arthritis, most involvement of ankles, midfoot joint and first metatarsophalangeal joint, with monosodium urate crystals deposition in synovial fluid and other tissues. We present a case of 53-year-old male, who had several nontender, white-yellow papules and plaques over his elbows, knees and arms with chalk-like substanc...

BACKGROUND Gout is a chronic disease of monosodium urate (MSU) crystal deposition. Although hyperuricaemia is the central risk factor for development of gout, not all people with hyperuricaemia have subclinical MSU crystal deposition or indeed, symptomatic disease. The aim of this systematic literature review was to identify factors that contribute to MSU crystallization. METHODS A search was...

Hyperuricemia results from an imbalance between the rates of production and excretion of uric acid. Longstanding hyperuricemia can lead to gout, which is characterized by the deposition of monosodium urate monohydrate crystals in the joints and periarticular structures. Because such deposits are resolved very slowly by lowering plasma urate with available drugs or other measures, the symptoms o...

INTRODUCTION Dual-energy computed tomography (DECT) has potential for monitoring urate deposition in patients with gout. The aim of this prospective longitudinal study was to analyse measurement error of DECT urate volume measurement in clinically stable patients with tophaceous gout. METHODS Seventy-three patients with tophaceous gout on stable therapy attended study visits at baseline and t...

© 2013 The Authors. doi: 10.2340/00015555-1393 Journal Compilation © 2013 Acta Dermato-Venereologica. ISSN 0001-5555 Gout is a clinical syndrome presenting with recurrent, painful arthritis caused by deposition of monosodium urate. Urate crystal deposits are usually detected in the synovial membranes, joint capsules, articular cartilage, and periarticular tissue, and, rarely, in extra-articular...

Very little is known about the aetiology of acute attacks of gout or the mode of action of colchicine in relieving them. Their relationship to high serum uric acid levels and urate deposition is obscure, for maintaining serum levels at normal together with a negative urate balance does not prevent their occurrence. Fortunately the vast majority of acute attacks readily respond to colchicine in ...

Acute gouty arthritis occurs when crystals of monosodium urate form and deposit in joints and connective tissue. These crystals then provoke the characteristic acute inflammatory response of gout (Seegmiller, 1965), and may accumulate chronically forming gouty tophi. Although deposition of urate crystals from hyperuricaemic body fluids is an essential requirement in the pathogenesis of gout, on...