We previously reported that the pressor action of propranolol was observed in the rat anesthetized with urethane. In the present study, rats, anesthetized with pentobarbitone or ether, treated with curare or unanesthetized, were used to investigate the influence of anesthetics on the blood pressure response to propranolol. Propranolol always produced a pressor response under these experimental ...

The majority of sensory physiology experiments have used anesthesia to facilitate the recording of neural activity. Current techniques allow researchers to study sensory function in the context of varying behavioral states. To reconcile results across multiple behavioral and anesthetic states, it is important to consider how and to what extent anesthesia plays a role in shaping neural response ...

25 26 The majority of sensory physiology experiments have used anesthesia to facilitate the 27 recording of neural activity. Current techniques allow researchers to study sensory 28 function in the context of varying behavioral states. To reconcile results across multiple 29 behavioral and anesthetic states, it is important to consider how and to what extent 30 anesthesia plays a role in shapin...

OBJECTIVE To compare tonal response properties of neurons in the primary auditory cortex of Sprague-Dawley rats anesthetized with urethane and ketamine-xylazine. METHODS Forty-five female Sprague-Dawley rats (200-250 g) were randomized into two groups and anesthetized with urethane or ketamine-xylazine. Tone pips were chosen as the stimuli to obtain the action potentials of the single neurons...

Respiratory activity is most fragile during sleep, in particular during paradoxical [or rapid eye movement (REM)] sleep and sleep state transitions. Rats are commonly used to study respiratory neuromodulation, but rodent sleep is characterized by a highly fragmented sleep pattern, thus making it very challenging to examine different sleep states and potential pharmacological manipulations withi...

serotonin is believed as an important factor in brain function. the role of serotonin in cerebral psycho-patho-physiology has already been well established. however, the function of serotonin antagonist in anesthetized subjects under hyperthermia has not been studied properly. methods: experiments were performed in three groups of urethane-anesthetized rats, such as: (i) control group, (ii) who...

Brain state alternations resembling those of sleep spontaneously occur in rats under urethane anesthesia and they are closely linked with sleep-like respiratory changes. Although rats are a common model for both sleep and respiratory physiology, we sought to determine if similar brain state and respiratory changes occur in mice under urethane. We made local field potential recordings from the h...

MacGowan, Guy A., Jennifer Rager, Sanjeev G. Shroff, and Michael A. Mathier. In vivo -adrenergic responses and troponin I phosphorylation: anesthesia interactions. J Appl Physiol 98: 1163– 1170, 2005. First published December 3, 2004; doi:10.1152/japplphysiol.00959.2004.—The mechanisms by which -adrenergic stimulation of the heart in vivo can cause contractile dysfunction are not well understoo...

The cochlea converts sound vibration into electrical impulses and amplifies the low-level sound signal. Urethane, a widely used anesthetic in animal research, has been shown to reduce the neural responses to auditory stimuli. However, the effects of urethane on cochlea, especially on the function of outer hair cells, remain largely unknown. In the present study, we compared the cochlear microph...

Most anesthetics induce characteristic hemodynamic changes leading to blood pressure (BP) reduction but the role of renin-angiotensin system (RAS), sympathetic nervous system (SNS) and nitric oxide (NO) synthesis in this BP reduction is unknown. We therefore studied the influence of four widely used anesthetics - pentobarbital (P), isoflurane (ISO), ketamine-xylazine (KX) and chloralose-urethan...