574 www.thelancet.com Vol 383 February 8, 2014 In May, 2012, a 55-year-old man was referred to our clinic for severe heart failure (New York Heart Association class IV). He had raised brain natriuretic peptide of 1053 ng/L (normal <55 ng/L) and his estimated ejection fraction by echocardiography was 25%. His medical history was mostly uneventful, apart from the fact that he had had both hips re...

This is a longitudinal study of the daily urinary output and the concentrations in whole blood of cobalt and chromium in patients with metal-on-metal resurfacings over a period of four years. Twelve-hour urine collections and whole blood specimens were collected before and periodically after a Birmingham hip resurfacing in 26 patients. All ion analyses were carried out using a high-resolution i...

The discovery (Smith, 1948; Rickes, Brink, Koniuszy, Wood & Folkers, 1948) that vitamin B,, contains cobalt immediately suggested that it might be possible to label the molecule with radioactive cobalt. A radioactive form of the vitamin would be invaluable for many biochemical investigations. However, as was rather to be anticipated from earlier experiments (Flagg, 1941; McCallum & Hoshowsky, 1...

During active blood regeneration in anemia in dogs an increase occurs in the stroma protein of the red cells. When vitamin B(12) with radioactive cobalt is given at the start of this blood regeneration one finds concentration of labeledB(12)in the stroma protein but not in the hemoglobin. After the acute phase of red cell regeneration is ended the concentration of B(12) in stroma protein falls ...

Objective: This study retrospectively investigates causes of death among workers of a hard-metal plant in Austria. Methods: A retrospective cohort was formed of 1965 workers still employed in or after 1970. Followup was until end of 2014 based on national data bases. Cobalt exposure was assessed through industrial hygiene data and urine analyses. Cox proportional hazards models were calculated ...

In support of a feasibility study of reproductive and developmental health among females employed in the Monchegorsk (Russia) nickel refinery, personal exposure and biological monitoring assessments were conducted. The inhalable aerosol fraction was measured and characterised by chemical speciation and particle-size distribution measurements. Unexpected findings were that: (i), pyrometallurgica...

Although 2:3-dimercaptopropanol (British AntiLewisite, BAL) was first introduced (Stocken & Thompson, 1941, 1946) as a local antidote for use after contamination of the skin with one of the arsenical vesicants, its application to the treatment of systemic arsenical poisoning in man made it desirable to obtain information concerning the distribution of thiols in the blood and urine after injecti...

UNLABELLED Our objective was to evaluate the relationship of urine metals including barium, cadmium, cobalt, cesium, molybdenum, lead, antimony, thallium, tungsten, and uranium with diabetes prevalence. Data were from a cross-sectional study of 9,447 participants of the 1999-2010 National Health and Nutrition Examination Survey, a representative sample of the U.S. civilian noninstitutionalized ...

BACKGROUND In Iran, an iodine deficiency control program was initiated in 1989 by iodizing salt. Despite this program, goiters have remained an endemic condition in most parts of Iran. Thus, it is possible that other factors aside from iodine deficiency may contribute to endemic goiter. The aim of this study was to investigate the association between cobalt deficiency and endemic goiter in a re...

BACKGROUND Five metal turners employed by an aerospace manufacturer presented to the Birmingham Chest Clinic occupational lung disease unit. Four cases of occupational asthma (OA) due to chromium salt (3) and cobalt (1) were diagnosed by serial peak-expiratory flow measurements and specific inhalation challenge testing. AIMS To measure the extent of the outbreak and to provide epidemiological...