Wing development in Drosophila requires the activation of Wingless (Wg) in a small stripe along the boundary of Fringe (Fng) expressing and non-expressing cells (FB), which coincides with the dorso-ventral (D/V) boundary of the wing imaginal disc. The expression of Wg is induced by interactions between dorsal and ventral cells mediated by the Notch signalling pathway. It appears that mutual sig...

in this study, displacement field around v-notches of a poly methyl metha crylate (pmma) specimen with tip cracks will be analyzed using digital image correlation technique. first intensity factor in combination with in-plane rigid body translations and rotation components will be determined by linear least squares fitting of the displacement field data to the corresponding relations among stre...

Fatigue damage detection and its classification in metallic materials are persistently challenging the structural health monitoring community. The mechanics of fatigue is difficult to analyze further complicated because presence notches different geometries. These act as possible crack-nucleation sites resulting failure mechanisms that drastically from one another. Often, sensor-based tools use...

myocardial fractional flow reserve (ffr) is a new index of the functional significance of intermediate coronary stenoses that is calculated from pressure measurements made during coronary arteriography. the aim of this study was to evaluate the correlation between non-hyperemic coronary pressure dicrotic notch and fractional flow reserve (ffr). a consecutive of 114 patients (73 men and 41 women...

The unavoidable occurrence of microdefects in silicon wafers increase the probability of catastrophic fracture of silicon-based devices, thus highlighting the need for a strengthening mechanism to minimize fractures resulting from defects. In this study, a novel mechanism for manufacturing silicon wafers was engineered based on nanoscale reinforcement through surface nanotexturing. Because of n...

The combined effects of an asymmetric (square or V-shaped) notch and uniaxial strain are studied in a zigzag graphene nanoribbon (ZGNR) device using a generalized tight-binding model. The spin-polarization and conductance-gap properties, calculated within the Landauer–Büttiker formalism, were found to be tunable for uniaxial strain along the ribbon-length and ribbon-width for an ideal ZGNR and ...

The difference in the potential energy in an elastic three-dimensional domain with a V-notch with and without a small crack ( δΠ ) under a general mixed mode I+II+III loading is provided as an asymptotic series. It involves the V-notch edge stress intensity functions, the area of the formed crack, and special geometrical functions that can be pre-computed and tabulated. Importantly, the stress ...

Among all tissues and organs, the mammary gland is unique because most of its development occurs in adulthood. Notch signaling has a major role in mammary gland development and has been implicated in breast cancer. The vacuolar-ATPase (V-ATPase) is a proton pump responsible for the regulation and control of pH in intracellular vesicles and the extracellular milieu. We have previously reported t...

Thin-plate weirs are commonly used as measuring devices in flumes and channels, enabling an accurate discharge measurement with simple instruments. The calibration formulae of such devices rely upon some empirical coefficients and there is a need to obtain new accurate physical data to complement the existing evidence. In the present study, the discharge calibration of a large 901 V-notch thin ...

Scour in bed material downstream weirs is considered the most unfavorable process which threats the overall stability of the weir. Weirs with oblique angle in the horizontal plan will affect the scour profile downstream the structure and may reduce it. The objective of this paper is to investigate the effect of oblique weir angle on the scour profile. Furthermore, the effect of V-notch angle on...