Primary clear cell adenocarcinomas most commonly involve the genitourinary system, including the vagina. Previously, primary clear cell adenocarcinomas of the vagina have been discussed within the context of prenatal exposure to diethylstilbestrol. Due to its widely proven role in the development of this carcinoma, administration of diethylstilbestrol is prohibited. We present two cases of non-...

primary clear cell adenocarcinomas most commonly involve the genitourinary system, including the vagina. previously, primary clear cell adenocarcinomas of the vagina have been discussed within the context of prenatal exposure to diethylstilbestrol. due to its widely proven role in the development of this carcinoma, administration of diethylstilbestrol is prohibited. we present two cases of non-...

background: vitamin d plays a critical role in the regulation of growth and differentiation of squamous epithelium. the pleiotropic effects of 1,25-dihydroxyvitamin d3 [1,25(oh)2d3], include proliferative, pro-apoptotic, and pro-differentiation effects on numerous cell types. although 1,25-dihydroxyvitamin d3 is involved in the regulation and differentiation of epithelium, there is no data in t...

introduction foreign body insertion is a common and important cause of pre-pubertal vaginal bleeding. case presentation we present a three-year-old girl who referred to our clinic with abnormal vaginal bleeding without any other symptoms. the primary assessment revealed a radio-opaque round solid mass in the pelvic cavity. following vaginoscopy, the button battery was finally removed under gene...

Female reproductive organs are mainly regulated by estrogen and progesterone. Specifically, the uterus, vagina and mammary gland show organ-specific mitosis and morphological changes during proliferative events, such as estrous cycle, gestation and lactation. The mechanism underlying these organ-specific estrogen-dependent events is still unknown. We examined, therefore, global gene expression ...

This investigation evaluated immunity to vaginal herpes simplex virus type 2 (HSV-2) infection after local or parenteral immunization with attenuated HSV-2. Vaginal immunization induced sterilizing immunity against challenge with a high dose of wild-type virus, whereas parenteral immunizations protected against neurologic disease but did not entirely prevent infection of the vagina. Vaginal imm...

herlyn-werner-wunderlich (hww) syndrome is an uncommon combined müllerian duct anomalies (mdas) and mesonephric duct malformation of female urogenital tract characterized by uterus didelphys and obstructed hemi-vagina and ipsilateral renal agenesis (ohvira) syndrome. we present a rare and unusual case of this syndrome in a 19 year-old female who suffered from hypomenorrhoea and abdominal pain. ...

Inverted-Y ureteral duplication is one of the rarest anomalies of ureteral branching. We encountered a 20-year-old female patient with persistent incontinence even after nephrectomy for ectopic ureteral insertion into the vagina. She had inverted-Y ureteral duplication between the bladder and vagina, and urine was being transported from the bladder to the vagina. To the best of our knowledge, t...