The effect of 12-month dehydroepiandrosterone (DHEA) replacement therapy has been evaluated in 14 60- to 70-yr-old women who received daily applications of a 10% DHEA cream. Vaginal epithelium maturation was stimulated by DHEA administration in 8 of 10 women who had a maturation value of zero at the onset of therapy, whereas a stimulatory effect was also seen in all three women who had an inter...

abstract background: menopause is associated with various complications such as depression, sleep disorders, and genitourinary atrophy. vaginal atrophy occurs due to the loss of steroid hormones, and its major symptoms include vaginal dryness, itching, dyspareunia, and bleeding after intercourse. according to the literature, vitamin e plays a key role in estrogen stability. the aim of this stud...

objective: in this study, we aimed at evaluation of the efficacy of hypericum perforatum and flaxseed on hot flash, vaginal atrophy and estrogen-dependent cancers in menopausal women materials and methods: we searched medline, scopus, and the cochrane central register of controlled trials (rct) to explore trials that assessed the effectiveness of h. perforatum and flaxseed on hot flash, vaginal...

Objective: In this study, we aimed at evaluation of the efficacy of Hypericum perforatum and flaxseed on hot flash, vaginal atrophy and estrogen-dependent cancers in menopausal women Materials and Methods: We searched MEDLINE, Scopus, and the Cochrane Central Register of Controlled Trials (RCT) to explore trials that assessed the effectiveness of H. perforatum and flaxseed on hot flash, vagina...

The estrogenic efficacy of topical vaginal application of Pueraria mirifica extract (PM) on the restoration of vaginal atrophy, and the presence of any systemic side effects, were investigated in postmenopausal cynomolgus macaques. Twelve postmenopausal cynomolgus macaques, with complete cessation of menstruation for at least 5 years before start of this experiment, were divided into three grou...

Objective: Most studies use clinical examination and evaluation of symptoms as subjective forms for the diagnosis vaginal atrophy. Vaginal hormonal cytology pH are objective commonly used, however, mainly treatment control purposes. Despite relevance early atrophy, we not aware that objectively or subjectively evaluate evolution parameters with this intention. The aim study was to assess if ins...

The G protein-coupled receptor Gpr54 and its ligand metastin (derived from the Kiss1 gene product kisspeptin) are key gatekeepers of sexual maturation. Gpr54 knockout mice demonstrate hypogonadotropic hypogonadism, but until recently, the phenotype of Kiss1 knockout mice was unknown. This report describes the reproductive phenotypes of mice carrying targeted deletions of Kiss1 or Gpr54 on the s...

BACKGROUND Menopause is associated with various complications such as depression, sleep disorders, and genitourinary atrophy. Vaginal atrophy occurs due to the loss of steroid hormones, and its major symptoms include vaginal dryness, itching, dyspareunia, and bleeding after intercourse. According to the literature, vitamin E plays a key role in estrogen stability. The aim of this study was to c...

Method Twenty female Sprague Dawley rat (SD rat) were randomly divided into two groups according to their bedding types. The 1 group was raised in wood shaving bedding as a control and 2 one was in corncob bedding as an endocrine disrupting agent. Each group was checked daily for the first day of vaginal opening, and their vaginal smears were collected to determine estrous cyclicity after vagin...