Two types of distamycin-linked hydroxamic acids (DHA), which contain various lengths of polymethylene chains (PM-DHA) and relatively rigid phenylene ones (Ph-DHA), have been synthesized for the first time. Their DNA cleavage specificities were investigated by an end-labeled fragment cleavage experiment in the presence of vanadyl ion and hydrogen peroxide. The DNA cleavage by the PM-DHA x VO(II)...

Oxovanadium(IV) complexes of the type [VO(mac)]SO4 , (where mac = tetraaza macrocyclic ligands derived by condensation of furil with 1,4-diaminobenzene or 3,4-diaminopyridine and their reaction with βdiketones) have been prepared using vanadyl ion as kinetic template. Tentative structures of the complexes have been proposed on the basis of elemental analysis, infrared, e.s.r. and electronic dat...

Since insulin-dependent diabetes mellitus (IDDM), which causes many severe secondary complications, is characterized by hyperglyceria due to absolute deficiency of insulin, the diseases is controlled by daily injection of insulin. Therefore, the development of insulin replacements of mimetics upon oral administration is an important investigation. Recent studies indicate that vanadium, which is...

Spontaneously hypertensive rats (SHR) are hyperinsulinemic compared with their Wistar-Kyoto (WKY) controls. Since previous studies have demonstrated that vanadyl sulfate lowers insulin levels in nondiabetic rats, we used vanadyl to explore the relation between hyperinsulinemia and hypertension. In a prevention study, 5-week-old SHR and WKY rats were started on long-term vanadyl sulfate treatmen...

The VO(IV) complexes of tridentate ONO Schiff base ligands derived from 2- aminobenzoicacid and salicylaldehyde derivatives were synthesized and characterized by IR, UV–Vis and elemental analysis. Electrochemical properties of the vanadyl complexes were investigated by cyclic voltammetry. A good linear correlation was observed between the oxidation potentials and the electron-withdrawing charac...