In diesem Beitrag dokumentieren wir eine Studie über den Einsatz von Tablets. Über mehrere Wochen wurde auf einer 9ten, 11ten und 12ten Klasse in verschiedenen Fächern ausschließlich mit iPads und interaktiven iBooks gearbeitet. Genauer ging es darum, zu untersuchen, in wie fern und mit welchem Arbeitsaufwand, interaktive Inhalte für unterschiedliche Fächer erstellt werden können und welches de...

The game complexity of Tetris was first studied by Erik demaine, Susan Hohenberger and David LibenNowell in “Tetris is hard" [1]. Their proof was later simplified in “Tetris is hard, made easy” [2]. The authors of the last two papers published a joint paper [3], In “Tetris is hard” they left open the question of the complexity of a variant of the game. In this variant, we can move and rotate a ...

OBJECTIVES The aim of this study was to assess the steady-state pharmacokinetic parameters of telavancin, an investigational bactericidal lipoglycopeptide, after intravenous (iv) administration to healthy male and female subjects. PATIENTS AND METHODS In a randomized, double-blind, parallel-group, gender-stratified, two-dose study, 79 adult subjects received three daily 60 min iv infusions of...

Volume of distribution and fraction unbound are two key parameters in pharmacokinetics. The fraction unbound describes the portion of free drug in plasma that may extravasate, while volume of distribution describes the tissue access and binding of a drug. Reliable in silico predictions of these pharmacokinetic parameters would benefit the early stages of drug discovery, as experimental measurin...

Until now, the major part of NMR Imaging studies were finalized to diagnostic goals. Hence the main subject of imaging works were the water mobile molecules of biological tissues. Other fields of recent interest were the ima ging of nuclei different from protons and high spatial resolution (NMR microscopy). Another branch of great intere st is the imaging of the broad band components of biologi...

In einem Pilotprojekt zum Wissensmanagement in der Luftfahrtindustrie wurde ein Werkzeug zur Darstellung und Abfrage von Wissensträgern konzipiert und prototypisch eingesetzt. Der dabei entwickelte Implementierungsprozess wird vorgestellt. Im Ergebnis zeigt das Projekt aus verschiedenen Perspektiven kulturelle und organisatorische Bedingungen und Grenzen für Wissensmanagement auf. 1 Überblick u...

Background: Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous disorder characterized by bone loss and bone fragility. The aim of this study was to investigate the variants of three genes involved in the pathogenesis of OI. Methods: Molecular genetic analyses were performed for COL1A1, COL1A2, and CRTAP genes in an Iranian family with OI. The DNA samples were analyzed by...

Die Energieversorgung der Zukunft und die Etablierung von intelligenten Stromnetzen (Smart Grids) soll mit der Umsetzung eines intelligenten Messwesens (Smart Metering) sicher und effizient ausgestaltet werden. Damit einher ging in der Vergangenheit die Umsetzung verschiedener europarechtlicher Vorgaben im Bereich des Energiewirtschaftsrechts. Vor allem die Einführung des Smart Metering in Deut...

The pharmacokinetics of AL-226, a new semi-synthetic cephalosporin, were studied after i.v. and i.m. administrations to rabbits at doses of 10, 20, 30 and 40 mg/kg. The average values of the pharmacokinetic parameters after bolus i.v. administration of the antibiotic expressed by an open two-compartment kinetic model were: alpha = 0.131 min.-1, beta = 0.0341 min-1, K12 = 0.0287 min.-1, K21 = 0....

Abstract Viroids are smallest, single-stranded, circular, highly structured plant pathogenic RNAs that do not code for any protein. Viroids belong to two families, the Avsunviroidae and the Pospiviroidae. Members of the Pospiviroidae family adopt a rod-like secondary structure. In this study the most stable secondary structures of citrus viroid variants that reported from Fars province wer...