conclusions our study indicated that ace-d and vegf-g alleles can be an independent risk factor for microalbominuria in t2dm patients. results a total of 255 consecutive patients with t2dm and microalbuminuria (group a) and 235 patients with t2dm and normoalbuminuria (group b) were included in the study. in univariate analysis, the groups were statistically similar for all variables, except for...

breast cancer is the most common cause of cancer-related death in female, after lung cancer. angiogenesis is essential for tumor growth and metastasis; therefore, antiangiogenesis strategies for treatment of cancer are currently an issue of interest. the role of vascular endothelial growth factor that assumed to be most potent angiogenesis factor is ambiguous in breast cancer. this study descri...

previous studies have demonstrated that vascular endothelial growth factor (vegf) can trigger angiogenesis as well as inflammation through binding to its membranous receptor-1 on endothelial and inflammatory cells. we aimed to correlate the circulatory number of cells expressing such receptor as well as the serum level of vegf and the soluble form of its receptor-1 (svegfr1) to the severity of ...

background: recently, the development of new biomarkers as prognostic and predictive markers in prostate cancer has been crucial. objectives: this study was aimed to determine whether serum vascular endothelial growth factor (vegf) levels would be a prognostic marker or risk assessment factor in patients with prostate cancer and to investigate whether it could differentiate cancerous tissue fro...

introduction: angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. cardiovascular endothelial factors are involved in diseases and vascular regulation.  stachys lavandulifolia belongs to the laminacea family and its hydroalcoholic extract is used as a traditional treatment to reduce pain and inflammation. the present study was conducted to ex...

vascular endothelial growth factor (vegf-a) is one of the most important regulatory factors in pathological and physiological angiogenesis. alternative splicing is a complicated molecular process in vegf-a gene expression which adds complexity to vegf-a biology. among all vegf-a exons, alternative splicing of exon 8 is the key determinant of isoform switching from pro-angiogenic vegf-xxx to ant...

introduction: pulsed dye laser (pdl) is an important treatment for superficial infantile hemangioma, but few studies report on its cellular mechanism. the aim of this study was to evaluate alterations of serum vascular endothelial growth factor (vegf) level in infantile hemangioma (ih) patients after laser treatment and effects of pdl irradiation on human umbilical vein endothelial cells (huvec...

background and objectives: angiogenesis is essential for growth and metastasis of solid malignancies. tumor vessel count and expression of vascular endothelial growth factor (vegf), a potent angiogenic factor, have been associated with prognosis. this study was designed to assess vessels density by using cd31 and cd105 (endoglin) and their correlation with expression of vegf and proliferative i...

background: the effects of the vascular endothelial growth factor (vegf) gene ?2578c/a polymorphism on colorectal cancer (crc) risk have been investigated in some studies; however, the results of these studies were conflicting and ambiguous. therefore, we aimed to do a meta-analysis to investigate the association of vegf ?2578c/a polymorphisms with crc risk from all eligible case-control studie...

background: surface properties of a biomaterial could be critical in determining biomaterial’s biocompatibility due to the fact that the first interactions between the biological environment and artificial materials are most likely occurred at material’s surface. in this study, the surface properties of a new nanocomposite (nc) polymeric material were modified by combining plasma treatment and ...