Subjects with obesity frequently have elevated serum vasopressin levels, noted by measuring the stable analog, copeptin. Vasopressin acts primarily to reabsorb water via urinary concentration. However, fat is also a source of metabolic water, raising possibility that might role in accumulation. Fructose has been reported stimulate vasopressin. Here, we tested hypothesis fructose-induced syndrom...

Recently, chronic hyponatremia, even mild, has shown to be associated with poor quality of life and high mortality. The mechanism by which hyponatremia contributes those symptoms, however, remains elucidated. Syndrome inappropriate secretion antidiuretic hormone (SIADH) is a primary cause hyponatremia. Appropriate animal models are crucial for investigating the pathophysiology SIADH. A rat mode...

objective nocturnal enuresis is a common childhood problem and has various  treatments. this study was carried out to compare oral and nasal vasopressin in the treatment of nocturnal enuresis in 5- to 12-year-old children who were referred to the shahid beheshti clinic in 2008. materials & methods this study included 100 children (62 males and 38 females) with nocturnal enuresis. one group (50 ...

Microtine rodents provide an excellent model for the study of the neurobiology of social bonds. In this review, we discuss how the presence of a microsatellite sequence in the prairie vole vasopressin receptor gene may determine vasopressin receptor binding patterns in the brain and how these patterns may in turn affect social behavior.

Vasopressin, a neurohypophyseal peptide hormone, is the endogenous agonist at V1a, V1b, and V2 receptors. The most important physiological function of vasopressin is the maintenance of water homeostasis through interaction with V2 receptors in the kidney. Vasopressin binds to V2 receptor and increases the number of aquaporin-2 at the apical plasma membrane of collecting duct principal cells. Th...

This study was designed to ascertain whether the extracellular loops of vasopressin/oxytocin receptors bind ligands and, if so, to locate the molecular determinants of this ligand-receptor interaction. Ligand-binding studies were employed using a rat liver V1a vasopressin receptor preparation and both peptide and non-peptide receptor ligands. Synthetic peptides corresponding to defined regions ...

Vasopressin is one of several small neuropeptides that are reported to be autocrine growth factors for small cell carcinoma of the lung (SCCL). It has been assumed that this peptide exercises its ntitogenic influences through the Vasopressin V,., receptor, and we have previously demon strated that this receptor is expressed by classical and variant SCCL. Activation of the vasopressin Vla recept...

Vasopressin is one of several small neuropeptides that are reported to be autocrine growth factors for small cell carcinoma of the lung (SCCL). It has been assumed that this peptide exercises its mitogenic influences through the vasopressin V1a receptor, and we have previously demonstrated that this receptor is expressed by classical and variant SCCL. Activation of the vasopressin V1a receptor ...