like) exhibit a pleiotropic phenotype including abnormalities of cardiac, skeletal and limb development, in addition to renal agenesis. Here we report abnormalities of gonad development in homozygous mutants. From early stages, Vcc/Vcc embryos contain gonads longer than controls and by 13.5 dpc this increased length is evidenced by an increase in the number of testis cords. The gene mutated in ...

Autophagy is the unique, regulated mechanism for the degradation of organelles. This intracellular process acts as a prosurvival pathway during cell starvation or stress and is also involved in cellular response against specific bacterial infections. Vibrio cholerae is a noninvasive intestinal pathogen that has been studied extensively as the causative agent of the human disease cholera. V. cho...

PURPOSE To evaluate the average and regional correlations of retinal nerve fiber layer (RNFL) thickness measured by StratusOCT (optical coherence tomography; Carl Zeiss Meditec, Inc., Dublin, CA) and GDx VCC (Laser Diagnostic Technologies, Inc., San Diego, CA). METHODS Eighty-nine subjects-27 normal, 21 with suspected glaucoma, and 41 with glaucoma-were included in this cross-sectional study....

PURPOSE To evaluate the structure-function relationships between retinal sensitivity measured by Humphrey visual field analyzer (HVFA) and the retinal nerve fiber layer (RNFL) thickness measured by scanning laser polarimetry (SLP) with variable corneal compensation (VCC) and enhanced corneal compensation (ECC) in glaucomatous and healthy eyes. METHODS Fifty-three eyes with an atypical birefri...

like) exhibit a pleiotropic phenotype including abnormalities of cardiac, skeletal and limb development, in addition to renal agenesis. Here we report abnormalities of gonad development in homozygous mutants. From early stages, Vcc/Vcc embryos contain gonads longer than controls and by 13.5 dpc this increased length is evidenced by an increase in the number of testis cords. The gene mutated in ...

BACKGROUND Outer membrane vesicles (OMVs) released from Gram-negative bacteria can serve as vehicles for the translocation of virulence factors. Vibrio cholerae produce OMVs but their putative role in translocation of effectors involved in pathogenesis has not been well elucidated. The V. cholerae cytolysin (VCC), is a pore-forming toxin that lyses target eukaryotic cells by forming transmembra...

like) exhibit a pleiotropic phenotype including abnormalities of cardiac, skeletal and limb development, in addition to renal agenesis. Here we report abnormalities of gonad development in homozygous mutants. From early stages, Vcc/Vcc embryos contain gonads longer than controls and by 13.5 dpc this increased length is evidenced by an increase in the number of testis cords. The gene mutated in ...

PURPOSE To compare the diagnostic accuracy of scanning laser polarimetry (SLP) parameters between images taken with enhanced corneal compensation (ECC) and those with variable corneal compensation (VCC) and to explore the effect of atypical birefringence patterns on this accuracy. DESIGN Cross-sectional observational study. PARTICIPANTS Forty-one healthy subjects and 92 patients with primar...

OBJECTIVE To analyze the benefit of voiding chain cystourethrography (VCC) [placing a radiographic opaque chain into the urethra and bladder and asking the patient to void under fluoroscopy] in the urodynamic evaluation of female bladder outlet obstruction (BOO). MATERIALS AND METHODS Females with post anti-incontinence operation voiding dysfunction who underwent urodynamic evaluation augment...

PURPOSE To investigate whether correction for atypical birefringence pattern (ABP) using scanning laser polarimetry with enhanced corneal compensation (SLP-ECC) reduces the severity of ABP compared with variable corneal compensation (SLP-VCC) and improves the correlation with visual function. DESIGN Prospective observational study. METHODS Normal and glaucomatous eyes enrolled from four cli...