Palonosetron hydrochloride is a longer-acting selective 5-HT3 receptor antagonist that has been approved for the prevention of chemotherapy-induced nausea and vomiting and is being evaluated for the prevention of postoperative nausea and vomiting. The objective of this study was to evaluate the physical and chemical stability of palonosetron hydrochloride 50 mcg/mL when mixed with any of the ne...

Sixty six patients undergoing elective valve surgery were randomized to receive rocuronium bromide 0.6 mg/Kg (Group R, n=22), pancuronium bromide 0.1 mg/Kg (Group P, n= 22) and vecuronium bromide 0.1 mg/Kg (Group V, n=22), Measurements of heart rate and arterial pressure (systolic, diastolic and mean) were noted at the following stages: 1) baseline when haemodynamics were stable for 2 minutes a...

Pipecuronium bromide (Arduan) is a bisquaternary, steroid-type neuromuscular blocking agent in clinical use in Eastern Europe. Before its introduction into clinical practice in the USA, in the first phase of this study the neuromuscular potency of pipecuronium was determined under "balanced" and enflurance anaesthesia by the cumulative log dose-response method in 30 patients each. In the second...

We have assessed general anaesthesia for day-case cataract surgery in 40 patients more than 60 yr of age. The patients were allocated randomly to receive either an infusion of propofol or etomidate-vecuronium-isoflurane anaesthesia. Patients in the propofol group experienced significant reductions in mean arterial pressure (42%) during anaesthesia. In the etomidate-vecuronium-isoflurane group t...

This paper presents a preliminary study of the effects anesthetics propofol, remifentanil, and vecuronium bromide on rheological properties glycated erythrocytes in vitro, modeling glycation by hyperglycemia observed diabetes. Viscoelastic aggregation kinetic parameters were determined using an erythrocyte rheometer optical chip aggregometer developed our laboratory. The results showed signific...

Rocuronium is a new nondepolarizing neuromuscular blocking drug. Its onset of action is comparable to that of succinylcholine, with good-to-excellent intubating conditions possible 1 minute after doses two times the ED95 (600 pg/kg). The ED9a of rocuronium is essentially the same for children as for adults. Its duration of action is similar to vecuronium, and it is shorter for children than for...