OBJECTIVE The application and timing of hemofiltration (continuous veno-venous hemofiltration, CVVH) in patients with acute renal failure (ARF) post cardiac surgery has been called into question because of uncertain short-term outcome. The aim of the present study was to identify how the timing of introduction of hemofiltration affects the morbidity and mortality in patients with ARF after card...

Abstract Background and Aims To observe the clinical efficacy safety of fractionated plasma separation adsorption integrated with continuous veno-venous hemofiltration (FPSA-CVVH) treatment in patients acute liver failure (ALF). Method In this retrospective study, we enrolled ALF (serum total bilirubin>10mg/dl or Model for End-Stage Liver Disease (MELD) Score>18) hospitalized from...

Continuous renal replacement therapy (CRRT) has been widely employed in the treatment of critically ill patients. This study aimed to compare the efficacy of CRRT such as continuous veno-venous hemofiltration (CVVH), continuous veno-venous hemodialysis (CVVHD) and continuous veno-venous hemodiafiltration (CVVHDF), in patients with acute hypernatremia following craniocerebral injury and cerebral...

BACKGROUND Microvesicles (MV) are extracellular vesicles known to be associated with cellular activation and inflammation. Hemofiltration is an effective blood purification technique for patients with renal failure and possibly also eliminates inflammatory mediators in the setting of sepsis. On the other hand, proinflammatory stimuli are induced by blood contacting the artificial membrane durin...

On induction of anesthesia (for intubation), the patient hemodynamics became very unstable prompting the initiation of both Epinephrine and Nor-Epinephrine Intra-venous (IV) infusions. Glucose 10% IV infusion and Insulin IV infusion were also started. The pre-transfer management also included Hydrocortisone IV justified by the marked hemodynamic instability and mediocre response to inotropic su...

Voriconazole is a first-line agent for treatment of systemic mycotic infections. However, intravenous use is contraindicated in patients with creatinine clearance <50 ml/minute because of accumulation of the toxic vehicle sulfobutyletherbeta-cyclodextrin sodium [1, 2]. In a recent issue of Critical Care, Kiser and colleagues furnished convincing pharmacological evidence that sulfobutylether-bet...

BACKGROUND An increased admission of high-risk patients to diagnostic and interventional radiological procedures with contrast medium has resulted in an increase of contrast-induced nephropathy, which now represents the third main cause of hospital-acquired acute renal failure. The pathogenic mechanism of contrast-induced nephropathy (CN) is unclear, but there is much evidence which indicated a...

We wanted to evaluate if brain natriuretic peptide (BNP) is cleared during continuous veno-venous hemofiltration (CVVH) sessions in children with congenital heart disease. A prospective observational single-center study was conducted in a post-cardiac surgery intensive care unit of the city children's hospital. Ten children requiring CVVH for acute kidney injury following cardiac surgery were e...

BACKGROUND Hemofiltration in the form of continuous venovenous hemofiltration (CVVH) is increasingly used to treat acute renal failure. Compared to hemodialysis, hemofiltration provides high clearances for large solutes but its effect on protein-bound solutes has been largely ignored. METHODS Standard clinical systems were used to remove test solutes from a reservoir containing artificial pla...

INTRODUCTION The primary aim of this study was to determine whether hypophosphatemia during continuous veno-venous hemofiltration (CVVH) is associated with the global outcome of critically ill patients with acute kidney injury (AKI). METHODS 760 patients diagnosed with AKI and had received CVVH therapy were retrospectively recruited. Death during the 28-day period and survival at 28 days afte...