Twenty-three normal adult volunteers underwent single eye visual-evoked potential (VEP) and blue field entoptic studies during suction cup-induced intraocular pressure (IOP) elevation, to determine whether IOP-induced changes in VEP are related to alterations in retinal capillary hemodynamics. VEP pressure tolerance testing through an ascending series of 6-8 IOP levels was carried out using a 7...

Visual evoked potential (VEP) abnormality is widely used as an objective indication of visual pathophysiology in the diagnosis of multiple sclerosis. One major limitation of this test is that VEP abnormality is not specific to multiple sclerosis. In an attempt to explore ways of making the VEP test more specific, changes were measured in VEPs caused by superimposing upon the VEP stimulus either...

The pattern VEP is frequently abnormal in multiple sclerosis. In this disease the VEP latency is prolonged and the amplitude is reduced. The use of the VEP amplitude in diagnosis is limited because of the large interand intrasubject variability and low signal-to-noise ratio (SNR). Goal of this project is to improve the SNR of VEP’s with alternative averaging procedures, and to investigate wheth...

Postoperative visual outcome is a major concern in transsphenoidal surgery (TSS). Intraoperative visual evoked potential (VEP) monitoring has been reported to have little usefulness in predicting postoperative visual outcome. To re-evaluate its usefulness, we adapted a high-power light-stimulating device with electroretinography (ERG) to ascertain retinal light stimulation. Intraoperative VEP m...

Introduction Studies comparing visual evoked potentials (VEPs) and BOLD signals have found a positive correlation between the VEP amplitude and the magnitude and extent of the BOLD signal [1, 2], but some VEP components are better related to the BOLD signal than others. The strongest spatial correlation have been found between the source location of the N1 peak* and the location of the BOLD sig...

A 36 kDa extracellular metalloprotease (designated to as vEP-MO6) was purified and characterized from Vibrio vulnificus sp. strain MO6 24/0. vEP-MO6 cleaved azocasein and a few other proteins such as prothrombin, plasminogen, fibrinogen and Factor Xa, which are associated with the blood coagulation pathway. The enzyme activity of vEP-MO6 was inhibited by EDTA, which was reversed by the addition...

The pattern VEP is frequently abnormal in multiple sclerosis. In this disease the VEP latency is prolonged and the amplitude is reduced. The use of the VEP amplitude in diagnosis is limited because of the large interand intrasubject variability and low signal-to-noise ratio (SNR). Goal of this project is to improve the SNR of VEP’s with alternative averaging procedures, and to investigate wheth...

The pattern VEP is frequently abnormal in multiple sclerosis. In this disease the VEP latency is prolonged and the amplitude is reduced. The use of the VEP amplitude in diagnosis is limited because of the large interand intrasubject variability and low signal-to-noise ratio (SNR). Goal of this project is to improve the SNR of VEP’s with alternative averaging procedures, and to investigate wheth...