Evaluation of four botanicals Vernonia amygdalina L., Bryophyllum pinnatum L., Eucalyptus globules Labill and Ocimum gratissimum Kurz (Clocimum) for chemical and nutritional properties was conducted at Ago Iwoye in South-western Nigeria. The results from the investigation showed that V. amygdalina contained large quantity of Thiamine, Pyridoxine, Ascorbic acid, Glycine, Cysteine and Casein hydr...

Many minor components of foods, such as secondary plant metabolites, have been shown to posses antioxidant activities, improving the effects of oxidative stress on diabetes and other disease conditions. This study evaluates the effect of aqueous extracts from Vernonia amygdalina leaves on lipid profiles and oxidative stress in streptozotocin induced diabetic rats. The results showed that the st...

BACKGROUND The emergence and spread of Plasmodium falciparum with resistance to chloroquine (CQ), the safest and cheapest antimalarial drug coupled with the increasing cost of alternative drugs especially in developing countries have necessitated the need to optimize antimalarial actions of plant extracts and restore chloroquine efficacy. OBJECTIVE The present study determines the ability of ...

Sub-acute Toxicity of Aqueous Extracts of Tephrosia vogelii, Vernonia amygdalina and Senna occidentalis in Rats Immaculate Nabukenya1*, Chris Rubaire-Akiiki1, Denis Mugizi1, John Kateregga1, Deogracious Olila1 and Johan Höglund2 1College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, P.O. Box 7062, Kampala, Uganda 2Department of Biomedical Sciences and Veterinary...

Background: Some locally available plant foods in Nigeria have received attention as dietary agents that modulate gastrointestinal functions and carbohydrate metabolism. Objective: The effect of some of these plant foods like Detarium microcarpium (legume) and Vernonia amygdalina (vegetable) on postprandial glucose response of healthy non-diabetic adults was investigated. These two studies were...

BACKGROUND Extracts of Vernonia amygdalina (V. amygdalina) have been shown to affect the serum lipid profile of some laboratory animals in previous studies. Its impact on serum lipid profile and the histological changes in atherosclerosis has not been studied. Our aim was to determine the effects of V. amygdalina on atherosclerotic lesions induced in rabbits on high-cholesterol diet. METHODS ...

Microtubules are among the most successful targets for anticancer therapy. This is evident because they play a key role in the process of mitosis and cell division. Many drugs have been developed that target microtubules for cancer treatment. Recent studies have shown that paclitaxel and vinca alkaloids are two of the most effective microtubule-targeted drugs. These drugs are considered to be v...

This study investigated the antidiabetic activity of the various combinations (ratios) of metformin (50 mg/kg) and aqueous extracts of the leaves of Vernonia amygdalina (100 mg/kg). The ratios of Extract to Metformin were 1:1, 2 1, and 2:1 and distilled water (control, p.o.) were given to both normoglycemic and alloxan-induced diabetic Wister albino rats. Blood was withdrawn and tested at 0, 1,...

Chikungunya virus is a reemerging arbovirus transmitted mainly by Aedes mosquitoes. As there are no specific treatments available, Chikungunya virus infection is a significant public health problem. This study investigated 120 extracts from selected medicinal plants for anti-Chikungunya virus activity. The plant materials were subjected to sequential solvent extraction to obtain six different e...

BACKGROUND An ethnobotanical study of medicinal plants was carried out in 14 villages adjacent to Mabira Central Forest Reserve (CFR) in Central Uganda between August 2013 and March 2014. METHODS Information was obtained through interviews using semi- structured questionnaires. Field excursions with traditional healers and herbal medicine collectors were carried out. Descriptive statistics we...