membrane/ protein trafficking in the secretory/ biosynthetic and endocytic pathways is mediated by vesicles. vesicle trafficking in eukaryotes is regulated by a class of small monomeric gtpases the rab protein family. rab proteins represent the largest branch of the ras superfamily gtpases, and have been concerned in a variety of intracellular vesicle trafficking and different intracellular sig...

Unconventional protein export/secretion (UPE/UPS), in contrast to the classical ER-Golgi-dependent of proteins with a leader sequence (signal peptide), employs multiple means release leaderless cargoes (and some special cases, sequence) extracellular space. By far, two major types UPE have been classified, vesicle-independent and vesicle-dependent UPE. In former, can directly tr...

Eukaryotic cells adhere to extracellular matrix during the normal development of organism, forming static adhesion as well cell motility. We study this process by considering a simplified coarse-grained model vesicle that has uniform energy with flat substrate, mobile-curved membrane proteins and active forces. find high concentration curved alone increases spreading vesicle, self-organization ...

We consider a stochastic perturbation of the phase field alpha-Navier-Stokes model with vesicle-fluid interaction. It consists in system nonlinear evolution partial differential equations modeling fluid-structure interaction associated to dynamics an elastic vesicle immersed moving incompressible viscous fluid. This couples phase-field equation -for interface between fluid and vesicle- fluid- e...

Objective- The aim of this study was to determine the first possible time for pregnancy recognition and several features of developing embryo between days 8 to 44 of pregnancy. Design- Experimental study Animals- Six healthy registered Caspian mares Procedures- Daily ultrasound examinations were conducted from days 8 to 44 (ovulation = day 0) of pregnancy to monitor the conceptus in Caspian ...

Background & Aims: Sodium arsenite causes oxidative stress and endocrine disorders in the reproductive system. The aim was to investigate the protective role of curcumin as an antioxidant on the seminal vesicle tissue in adult mice treated with sodium arsenite. Materials & Methods: Adult male Naval Medical Research Institute (NMRI) mice were randomly divided into 5 groups (six mice per group) ...

background: routine oocytes cryopreservation remained an elusive technique in the wide ranges of available assisted reproductive technologies. the microtubules of oocytes are vulnerable to cryoprotectants and thermal change during cryopreservation. objective: the effects of a vitrification protocol were investigated on the spindle and chromosome configurations of mice oocytes cryopreserved at t...