HYPOTHESIS The genesis, morphology, and growth characteristics of vestibular schwannomas are determined by genetic alterations which vary gene transcript expression and this transcript expression can be qualitatively and quantitatively evaluated using the SAGE technique. By use of such technique, gene products with tumorigenic potential may be identified, providing insight and targets for futur...

s/Presentations: Yue, WY, Woodson, E, Tryggvason, G, Clark, JJ, Hansen, MR. p75 is overexpressed in vestibular schwannomas and protects cells from apoptosis due to suppressed c-Jun N-terminal kinase (JNK) activity. American Association for Cancer Research, Washington DC, April 2010. Yue, WY, Clark, JJ, Domann, F, Hansen, MR. Persistent C-Jun N-terminal kinase activity contributes to the surviva...

OBJECTIVES With rising quality of speech perception in cochlear implant users, the indication widens. Nowadays, cochlear implantation is reasonable even in vestibular schwannoma patients. Speech perception with a cochlear implant is in these patients as promising as in patients with sensorineural hearing loss. However, the impact of cochlear implantation on vertigo and tinnitus after removal of...

OBJECTIVE To assess the outcome of conservative management of vestibular schwannoma. STUDY DESIGN Observational study. SETTING Tertiary referral centre. PATIENTS Four hundred and thirty-six patients with vestibular schwannoma (490 tumours), including 327 sporadic tumours and 163 tumours in 109 patients with neurofibromatosis type two. MAIN OUTCOME MEASURES The relationship of tumour gro...

The objectives of this study were to identify signs of vestibular nerve suffering through a bedside vestibular examination protocol in case of sudden sensorineural unilateral hearing loss without spontaneous signs of vestibular impairment and to propose a bed-side vestibular examination based protocol for the focused execution of gadolinium-enhanced magnetic resonance imaging (MRI) only if a ve...

Acoustic neuromas (vestibular schwannomas) are generally slow-growing, intracranial extra-axial benign tumors that usually develop from the vestibular portion of the eighth nerve. Unilateral vestibular schwannomas account for approximately 8% of all intracranial tumors; one of every 100,000 individuals per year develops a vestibular schwannoma.103 Bilateral vestibular schwannomas are usually as...

Vestibular schwannomas are relatively rare intracranial tumors compared to other brain tumors. Data on the molecular features, especially schwannoma proteome, scarce. The 41 cerebrospinal fluid (liquor) samples were obtained during surgical removal of vestibular schwannoma. Obtained peptide analyzed by shotgun LC-MS/MS high-resolution mass spectrometry. same spiked with 148 stable isotopically ...

Vestibular schwannomas are slow-growing, benign tumours. Microsurgery has been the standard treatment for vestibular schwannoma over the past 30 years. Following the introduction of stereotactic radiosurgery for the treatment of vestibular schwannoma in 1969, its increasing use worldwide had led to its acceptance by many as a safe and efficient alternative to microsurgery. The primary advantage...

OBJECTIVE To assess vestibular function in a large group of vestibular schwannoma patients so that we could determine whether simple vestibular exercises speed vestibular dysfunction recovery after tumor removal surgery. STUDY DESIGN A prospective investigation of the vestibular dysfunction experienced by patients in the first 12 weeks after surgery. SETTING Vestibular investigation unit at...

OBJECTIVES To study the spectrum of diseases that can be detected by magnetic resonance imaging in patients suspected to have vestibular schwannoma (acoustic neuroma) presenting with sensorineural or mixed hearing loss, and to assess the extent of the problem of hearing loss in a screened population. DESIGN Retrospective study. SETTING Diagnostic radiology and imaging department of a region...