نتایج جستجو برای: vinblastine
تعداد نتایج: 3670 فیلتر نتایج به سال:
Based on recent statistical survey, the cancer is the third important factor in Iran mortality. Vinblastine and vincristine alkaloids are dominantly biosynthesized in the aerial parts of periwinkle, broadly applied for cancer treatment. Therefore, over production of these alkaloids by using the biotechnological approaches is inevitable. Since the terpenoid indole alkaloids (TIAS) biosynthesis p...
Several fungal endophytes were isolated from some medicinal plants and screened for their ability to produce the anticancer drug vinblastine. An isolate was found vinblastine (205·38 ?g l?1), identity of confirmed by UV spectroscopic, high?performance liquid chromatography electrospray ionization mass spectrometry analyses. Based on both morphological molecular studies, vinblastine?producing st...
Catharanthus roseus L. is a medicinal plant that produces numerous indole terpenoid alkaloids, including vincristine and vinblastine, which are used for cancer treatment. The effect of specified precursors (L-phenylalanine, L-tyrosine) elicitors (chitosan, methyl jasmonate) on C. hairy roots (CHR) growth has been examined in order to increase the content vinblastine. Our results showed CHR gene...
Currently, there is no therapy for men with androgen-refractory prostate cancer that substantially extends survival. This report characterizes by in vitro and in vivo techniques a new chemotherapeutic that is composed of desacetyl-vinblastine covalently linked to a peptide that contains a peptide bond that can be hydrolyzed by prostate-specific antigen (PSA). This compound (referred to as vinbl...
Vinblastine is an important anticancer agent known to diminish microtubule assembly. Ab initio calculations are applied to examine the structural properties and different energies of vinblastine-tubulin complex in different dielectric constants and temperatures. The aims of this work are discovery the best optimized structure and thermodynamic properties of vinblastine-tubulin complex ...
objective(s):neurotoxicity of anticancer drugs complicates treatment of cancer patients. vinblastine (vbl) is reported to induce motor and cognitive impairments in patients receiving chronic low-dose regimen. materials and methods: the effects of vbl treatment on motor, learning and memory functions of male and female wistar rats were studied by behavioral related tests. animals were given chro...
Differential toxicity of vincristine and vinblastine against cells of a cloned subline of human promyelocytic leukemia (HL-60/Cl) was dependent on exposure conditions. During continuous exposures of 48 h, vincristine and vinblastine were equitoxic with drug concentrations that inhibited proliferation rates by 50% of 7.6 and 8.1 nM, respectively. When cells were subjected to 4-h exposures and tr...
TAKANO, S. Difference in Effects o f Vinblastine and V incristine on the Dog Platelet Aggregation. Tohoku J. exp. Med., 1981, 135 (1), 79-85 The present study was attempted to determine difference in effects of vinblastine and vincristine on ADP-induced aggregation of dog platelets. Vinblastine manifested biphasic influence depending upon concentrations, i.e., in low concentrations (0.2-20 ,ug/...
in this study, monte carlo statistical mechanical simulations for vinblastine and vincristine werecarried out in standard manner using the metropolis sampling technique in canonical (t, v, n)ensemble., geometrical optimizations of vinblastine and vincristine were carried out with the hfmethod coupled to 6-31g(d) basis sets for all atoms. simulation was done by four force fields ofmm+, bio+, amb...
Vinca alkaloids used in anticancer therapy are the well-known vinblastine and vincristine as classical antitumor agents. These dimeric molecules consist of two monomers, vindoline catharanthine, which have no particular activity on their own. The goal our research work was to obtain derivatives one these, vindoline, resulted with important antiproliferative effect. This type were hybrids; conju...
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