PURPOSE Viral conjunctivitis is a highly contagious infection often causing major epidemics. A safe broad-spectrum antiviral agent is needed to treat this unmet medical need. The purpose of this study is to demonstrate that in vitro NVC-422 is a safe, broad-spectrum topical virucidal agent with activity against ophthalmic viral pathogens. METHODS The virucidal activity of NVC-422 against seve...

BACKGROUND There is a clinical need for new therapeutic products against Herpes simplex virus (HSV). The pomegranate, fruit of the tree Punica granatum L, has since ancient times been linked to activity against infection. This work probed the activity of pomegranate rind extract (PRE) and co-administered zinc (II) ions. MATERIALS AND METHODS PRE was used in conjunction with zinc (II) salts to...

Crude extracts of leaves and bark of E. jambolana were tested for antiviral activity against highly pathogenic avian influenza virus (H5N1) by CPE reduction assay in three different layouts to elucidate virucidal, post-exposure and preexposure antiviral activity of the extracts. The cold and hot aqueous extracts of bark and hot aqueous extract of leaves of E. jambolana showed significant viruci...

Topical microbicides for use by women to prevent the transmission of human immunodeficiency virus (HIV) and other sexually transmitted infections are urgently required. Dendrimers are highly branched nanoparticles being developed as microbicides. SPL7013 is a dendrimer with broad-spectrum activity against HIV type I (HIV-1) and -2 (HIV-2), herpes simplex viruses type-1 (HSV-1) and -2 (HSV-2) an...

The article presents the results of study toxic and virucidal action disinfectant ‘Biolaid’, which includes hydrogen peroxide, lactic acid, supralactic acid. research was conducted following ‘Methodical Approaches to Control Disinfectants for Veterinary Medicine’ (Kovalenko Nedosiekov, 2011). Toxicity ‘Biolaid’ characterized in SPEV BHK-21/C13 cell cultures (ATCC CCL-10). Determination activity...

Several chemical disinfectants have been tested in a quantitative suspension test for virucidal activity as per the test method devised by the German Society for Control of Viral Diseases (DVV) and the former German Federal Health Office (BGA, now the Robert Koch-Institute, RKI) drafted in 1982. The introduction of the term "limited virucidal activity" (effective against enveloped viruses) in a...

JOHANSON, R. 1953 New specific reagent for keto-sugars. Nature, 172, 956-957. KOEHLER, L. H. 1952 Differentiation of carbohydrates by anthrone reaction rate and color intensity. Anal. Chem., 24, 1576-1579. PALMER, A. 1951 The specific determination and detection of glucose as a probable constituent radical of certain fructosans by means of notatin. Biochem. J., 48, 389-394. SHAFFER, P. A., AND ...

The bactericidal activity of 3-propiolactone (BPL) vapor was first reported by Hoffman and Warshowsky (1958). Although this chemical has shown promise in our laboratories as a very useful gaseous disinfectanit for rooms and buildings, the lack of information on the virucidal activity of BPL vapor has been a deterrent in the use of the chemical to decontaminate virology laboratories or buildings...

The bactericidal activity of 3-propiolactone (BPL) vapor was first reported by Hoffman and Warshowsky (1958). Although this chemical has shown promise in our laboratories as a very useful gaseous disinfectanit for rooms and buildings, the lack of information on the virucidal activity of BPL vapor has been a deterrent in the use of the chemical to decontaminate virology laboratories or buildings...