hepatitis c virus (hcv) envelope glycoprotein-2 (e2) inhibits the interferon (ifn)–induced, double –stranded rna activated protein kinase (pkr) via pkr eukaryotic initiation factor-2α phosphorylation homology domain (pephd). present study examined the genetic variability of the pephd in patients receiving interferon therapy. the pephd region from hcv genotype 1a/1b infected patients receiving i...

purpose: a 12 year-old boy and a known case of job’s syndrome presented with a large conjunctival mass which represented coexistence of hpv and hsv infections. case report: the presence of hpv virus within these lesions was confirmed by biopsy and dna analysis. the mass lesions did not respond to anti-hpv therapy with topical interferon-α2b, oral cimetidine and oral acyclovir, but improved prom...

hepatitis c virus is one of the main reasons for chronic liver disease and hepatocellular carcinoma. combination therapy with interferon (peg-ifn-α) and ribavirin (rbv) clear the virus more likely than the others. different factors like virus and host characteristics influence on response to treatment. the most important viral factors include virus genotype and viral load; host factors like gen...

The recent outbreak of COVID-19 is considered to be one of the biggest disasters faced in the history which has already killed 211568 and effected 3065739 people across the world (As on 28th April 2020). Thus, there is an alarming need to discuss novel treatment strategies for treatment of such viral outbreaks. Viral diseases affect millions of people around the world, with a major effect on hu...

evidence acquisition medline, pubmed, ovid and embase were used to search for clinical studies comparing with or without prophylactic use of lamivudine for hbv reactivation in breast cancer patients receiving chemotherapy. outcomes of interest were the rate of hbv reactivation, incidence of hepatitis and incidence of hepatitis attributable to hbv reactivation, severity of hepatitis and severity...

Background: In gene therapy, the use of RNA molecules as therapeutic agents has shown advantages over plasmid DNA, including higher levels of safety. However, transient nature of RNA has been a major obstacle in application of RNA in gene therapy. Methods: Here, we used the internal ribosomal entry site of encephalomyocarditis virus and the 3’ non-translated region of Poliovirus to design an en...

Background: Sodium valproate, an anticonvulsant drug, is reported to stimulate Human Immunodeficiency Virus type 1 and Human cytomegalovirus replication. Since epileptic patients undergoing sodium valproate therapy may suffer from various virus infections, the effect of this drug on replication of viruses especially those affecting neuronal tissues such as Herpes simplex virus type 1 is worthy ...

introduction various types of dermatological manifestations have been reported due to hepatitis c virus (hcv) infection and anti­hcv therapy. some of them have been described during ifn-based therapies. peg-ifn-α-2a/rbv combination is used as the international standard of treatment for hcv infection for a long time. the combination therapy yields an adverse-event profile similar to standard int...

This paper investigates the impact of various parameters mathematical model for Hepatitis B virus-Hepatitis D virus (HBV-HDV) co-infection with controls (awareness, vaccine and therapy). It establishes that is biologically meaningful epidemiologically well posed. Furthermore, simulations are carried out on equations using MATLAB results indicate that; when $c_1$(awareness) increase from $0.08$ ...

background: hepatitis g virus (gbv-c) is a single strand rnapositive virus and is a member of flaviviridae family. infection with the virus is prevalent add has worldwide distribution. accurate diagnosis of the virus is very important, because of co-infection with other important viruses like hcv, hbv and hiv, it may influence on pathogenesis, disease progression and response to viral therapy. ...