Objective: To determine prospectively plasma levels of vitamin B12 in diabetic patients with liver cirrhosis before and 3 months after vitamin administration and its effects on nutritional state of patients. Additionally study a new dosage form of vitamin B12 (buccal film) in compare to traditional one as intramuscular injection. Methods: 120 blood samples were collected from 60 adult cirrhotic...

BACKGROUND There is a growing focus on nutritional therapy for Alzheimer's disease (AD), and controversy exists regarding the association between AD and homocysteine (Hcy), vitamin B12, and folate levels. OBJECTIVE The present study evaluated the association between AD and the combined levels of Hcy, vitamin B12, and folate. METHODS This case-control study consisted of 115 patients with AD ...

The vitamin B12 levels of cerebrospinal fluid were assayed microbiologically (Lactobacillus leichmannii method) using samples from 44 patients with various neurological disorders, 4 patients with megaloblastic anemia and 34 controls. Twenty-seven controls that did not receive vitamin B12 showed a mean cerebrospinal fluid vitamin B12 level of 21.5 pg/ml (range: 0-60). No decrease in cerebrospina...

279 14.1 Role of vitamin B12 in human metabolic processes Although the nutritional literature still uses the term vitamin B12, a more specific name for vitamin B12 is cobalamin. Vitamin B12 is the largest of the B complex vitamins, with a relative molecular mass of over 1000. It consists of a corrin ring made up of four pyrroles with cobalt at the centre of the ring (1, 2). There are several vi...

Substantial amounts of vitamin B12 were found in some edible algae (green and purple lavers) and algal health food (chlorella and spirulina tablets) using the Lactobacillus delbrueckii subsp. lactis ATCC7830 microbiological assay method. Corrinoid-compounds were purified and characterized from these algae to clarify the chemical properties and bioavailability of the algal vitamin B12. True vita...

The usual dietary sources of vitamin B12 are animal foods, meat, milk, egg, fish, and shellfish. As the intrinsic factor-mediated intestinal absorption system is estimated to be saturated at about 1.5–2.0 lg per meal under physiologic conditions, vitamin B12 bioavailability significantly decreases with increasing intake of vitamin B12 per meal. The bioavailability of vitamin B12 in healthy huma...

BACKGROUND More than 2.9 million serum vitamin B12 tests were performed in 2010 in Ontario at a cost of $40 million. Vitamin B12 deficiency has been associated with a few neurocognitive disorders. OBJECTIVE To determine the clinical utility of B12 testing in patients with suspected dementia or cognitive decline. METHODS Three questions were addressed: Is there an association between vitamin...

OBJECTIVES This study aims to assess the usefulness of serum holotranscobalamin (holoTC), the fraction of vitamin B12 that is available for tissue uptake, compared with total vitamin B12 in patients investigated for vitamin B12 disorders. METHODS Serum samples were randomly selected from 76 patients (48 females, 28 males; age range 12-69 years) referred to the Clinical Biochemistry Laboratory...

the present study was performed to investigate the effects of long-term intraperitoneal (ip) injection of vitamin b12 and diclofenac in separate and combined treatments on cold and mechanical allodynia in a neuropathic pain model in rats. neuropathic pain was induced by crush injury in right tibial nerve. acetone spray and von frey tests were used to obtain cold and mechanical allodynia respons...