Background and Aims: Vitamin D plays an important role in bone health, cardiovascular health, brain development, immune system regulation, mood regulation, and cancer prevention. This study aimed to evaluate the vitamin D status and the prevalence of vitamin D deficiency in Jirof city, Kerman Province, south of Iran. Materials and Methods: In this cross-sectional study, 5243 people were select...

Vitamin D is a pro-hormone that plays an important role in body calcium regulation. Vitamin D toxicity occurs rarely due to its wide therapeutic index. A 38-year-old Iranian man was admitted to our hospital with a diagnosis of vitamin D toxicity. Laboratory test revealed hypercalcemia and elevated 25-hydroxyvitamin D (25(OH)D) level. Despite the cessation of vitamin D intake and diuretic treatm...

The maximum daily dose of vitamin D currently recommended is 2000 IU. Ergocalciferol (D2) 50,000 IU orally weekly for 8-12 weeks is often used to treat vitamin D deficient patients (25(OH) vitamin D <20 ng/mL). The lack of vitamin D toxicity after massive doses of ergocalciferol has yet to be reported in the literature. We report a case of a 56-year-old woman who received supratherapeutic doses...

Although researchers first identified the fat-soluble vitamin cholecalciferol almost a century ago and studies have now largely elucidated the transcriptional mechanism of action of its hormonal form, 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], we know surprisingly little about mechanisms of vitamin D toxicity. The lipophilic nature of vitamin D explains its adipose tissue distribut...

Vitamin D intoxication is a hypercalcemic and hypercalciuric state which is suggestive of excess 1,25(OH) 2 D-like activity. Major aspects of vitamin D toxicity have been reviewed by Coburn and Barbour [1] and by Stern and Bell [2]. Among the factors that may predispose individuals to vitamin D intoxication are increased calcium intake, decreased renal function, diminished estrogen levels, the ...

Abstract: &#x0D; Introduction and purpose: This review aims to analyze causes, symptoms diagnosis of overdosing vitamin D resulting in toxicity (VDT). Material method: paper was based on medical articles collected Pubmed from 2008 2021 year. The research has been done by looking through keywords such as “vitamin D” “toxicity”. Results: studies showed that manifestation VDT is mainly associated ...