Von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome characterized by the development of multiple vascular tumours. The syndrome is caused by inactivation of the VHL protein (pVHL) and increased production of VEGF, PDGF, and TGF-α. The course of VHL syndrome is associated with the development of multiple vascular tumours. Most frequently, these include retinal and central nervous sys...

Santi Sakdarat1*, Aussavashai Shuyprom2, Thaweephol Dechatiwongse Na Ayudhya2, Peter G. Waterman3, Gloria Karagianis3 1 School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand 2 Medicinal Plant Research Institute, Department of Medical Science, Ministry of Public Health, Nonthaburi, Thailand 3 Centre for Phytochemistry, Southern Cross Universit...

Von Hippel-Lindau disease (VHL disease) is a hereditary cancer predisposition syndrome caused by mutations of the von Hippel-Lindau tumor suppressor gene. The gene product, pVHL, regulates the level of proteins that play a central role in protecting cells against hypoxia. Clinical hallmarks of von Hippel-Lindau disease are the development of central nervous system hemangioblastomas, renal cell ...

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We report an unusual case of a young male with cerebellar hemangioblastoma treated previously for medullary carcinoma of thyroid, whose PET/CT scans revealed a constellation of findings that suggested the rare Von Hippel Lindau syndrome. The diagnosis was clinched by confirming the findings on whole body contrast enhanced computed tomography (CECT) and contrast enhanced magnetic resonance imagi...

CONTEXT Von Hippel-Lindau disease is an inherited syndrome of multiorgan neoplasia caused by a germline mutation in the von Hippel-Lindau gene and can include central nervous system tumors, renal cell carcinomas and benign pancreatic cystic tumors. CASE REPORT We report the case of a 56-year-old patient who had a past history of cerebellar hemangioblastoma and presented with abdominal pain. I...

A probable diagnosis of von Hippel-Lindau disease was made in a two generation family in which the proband had a phaeochromocytoma, renal cysts, and multiple cerebral cavernomas. His sister had multiple similar cerebral vascular lesions and his father died from renal carcinoma aged 42. Although the family did not satisfy the conventional diagnostic criteria for von Hippel-Lindau disease, an und...

1Goethe-Universität Frankfurt am Main, Institut für theoretische Physik, Max-von-Laue-Straße 1, D-60438 Frankfurt am Main, Germany 2Computation-based Science and Technology Research Center, The Cyprus Institute, 20 Kavafi Street, 2121 Nicosia, Cyprus 3Department of Physics, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus 4NIC, DESY, Platanenallee 6, 15738 Zeuthen, Germany 5Università...