Brandeis University, Waltham, MA 02454 9 10 11 12 13 14 15 Running title: Activity regulates PSD-95-mediated synaptic strengthening 16 17 Correspondence: John E. Lisman 18 Biology Department and Volen Center for Complex Systems 19 Brandeis University, Waltham, MA 02454 20 E-mail: [email protected] 21 Phone: 781-736-3145 22 Fax: 781-736-3107 23 24 25 Articles in PresS. J Neurophysiol (November...

OBJECTIVE To estimate the incremental cost-effectiveness of clinically proven nonsurgical commercial weight loss strategies for those with BMIs between 25 and 40. METHODS We performed a systematic literature review to identify randomized controlled trials of commercially available weight loss studies of at least 1 year in duration. Using the results of these trials and publicly available cost...

KP-736, a new cephen antibiotic with a broad antibacterial spectrum and potent antipseudomonal activity, was evaluated for in vitro antibacterial activity in comparison with ceftazidime, cefotaxime, and cefpirome. KP-736 was significantly more active than the test compounds against gram-negative bacteria, including the Pseudomonas group and ceftazidime-, cefotaxime-, or imipenem-resistant strai...

The iron hormone hepcidin is inhibited by matriptase-2 (MT2), a liver serine protease encoded by the TMPRSS6 gene. Cleaving the bone morphogenetic protein (BMP) coreceptor hemojuvelin (HJV), MT2 impairs the BMP/son of mothers against decapentaplegic homologs (SMAD) signaling pathway, down-regulates hepcidin, and facilitates iron absorption. TMPRSS6 inactivation causes iron-deficiency anemia ref...

Ringwoodite ( -Mg2SiO4) is the stable polymorph of olivine in the transition zone between 525–660 km depth, and can incorporate weight percent amounts of H2O as hydroxyl, with charge compensated mainly by Mg vacancies (Mg2+ = 2H+), but also possibly as (Si4+ = 4H+ and Mg2+ + 2H+ = Si4+). We synthesized pure Mg ringwoodite containing 2.5(3) wt% H2O, measured by secondary ion mass spectrometry (S...

We investigated the mechanisms that induce atrophy of the chicken bursa of Fabricius (BF) upon lipopolysaccharide (LPS) treatment in young chicks. LPS treatment resulted in ∼36% decrease in bursal weight within 36 h (P < 0.01). Histological analysis showed infiltration of eosinophilic heterophils and nucleated oval shaped RBCs in or near blood vessels of the BF from LPS-treated chicks. Scanning...

1 School of Kinesiology and Health Science, Faculty of Health, Muscle Health Research Center and 5 Physical Activity and Chronic Disease Unit, York University, 4700 Keele St., Toronto, ON, Canada, M3J 6 1P3 7 *Co-AuthorsBoth identified authors contributed equally to this entire manuscript. 8 9 **Corresponding Author: Dr. Michael Riddell, School of Kinesiology and Health Science, Faculty of 10 H...

Sapogenins are relatively cheap raw materials for the synthesis of a number of medicinally important steroids. Diosgenin is an aglycone of the steroidal saponin, dioscin, in yam and is a principal raw material for the industrial production of steroid drugs. It belongs to triterpene group and is of great interest to the pharmaceutical industry because of its estrogenic effect on the mammary glan...