Weight-dependent loading of the skeleton plays an important role in establishing and maintaining bone mass and strength. This review focuses on mechanical signaling induced by body weight as an essential mechanism for maintaining bone health. In addition, the skeletal effects of deviation from normal weight are discussed. The magnitude of mechanical strain experienced by bone during normal acti...

Chronic administration of chlorphentermine to rats resulted in a reduction of body weight compared to a normal control group. The weight of the heart, liver, kidney, and spleen was less in the treated group while the weight of the lungs was increased significantly. There was no change in the ratio of right ventricular to left ventricular weight in the rats treated with chlorphentermine, support...

A popular saying claims that "innovation is 1% inspiration and 99% perspiration." In this paper, we present a method for automating most of the perspiration involved in innovative design. We restrict our attention to innovative design processes which can be structured into three steps: discovery of a new technique, understanding it, and generalizing it to t the problem at hand. The method we de...