The toxicity and mutagenic potential of most African plants implicated in the management of cancer have not been investigated. The ethanolic extracts of selected Nigerian plants were subsequently studied using the brine shrimp lethality tests, inhibition of telomerase activity and induction of chromosomal aberrations in vivo in rat lymphocytes. Morinda lucida root bark, Nymphaea lotus whole pla...

The whole plant, Pergularia daemia (Family: Asclepediaceae), was extracted with 50% alcohol and a fresh batch of the plant material was successively extracted with petroleum ether, ethyl acetate and n-butanol to determine its diuretic activity. The diuretic activity of the different extracts at a dose of 400 mg/Kg was assessed orally in rats with furosemide as a standard drug using Lipschitzs t...

Introduction: Silymarin is obtained from Silybum marianum (milk thistle), an edible plant that has long been used medicinally for the treatment of liver-related disorders. Silymarin is a powerful hepatoprotective and antioxidant but the anticlastogenic activity, which is an important aspect of its cancer chemoprevention is not known hence the present investigation was carried out to study its...

The whole plant, Pergularia daemia (Family: Asclepediaceae), was extracted with 50% alcohol and a fresh batch of the plant material was successively extracted with petroleum ether, ethyl acetate and n-butanol to determine its diuretic activity. The diuretic activity of the different extracts at a dose of 400 mg/Kg was assessed orally in rats with furosemide as a standard drug using Lipschitzs t...

The free radical scavenging activities of n-hexane extract of the whole plant of Emilia sonchifolia was evaluated by employing various in vitro assay systems like DPPH radical scavenging activity, superoxide radical scavenging activity and hydrogen peroxide scavenging activity with IC50 values 180, 160 and 160 μg/ml respectively. The results of the study indicate that the n-hexane extract of th...

Tewtrakul, S., Subhadhirasakul, S., Kummee, S Anti-HIV-1 integrase activity of medicinal plants used as self medication by AIDS patients Songklanakarin J. Sci. Technol., 2006, 28(4) : 785-790 The extracts of selected medicinal plants used as self medication by AIDS patients were investigated for their inhibitory activities against HIV-1 integrase (HIV-1 IN) using the multiplate integration assa...

HIV is the etiological agent of AIDS that has created major health care problem throughout the world. The aim of the present study is to evaluate the cytotoxic effects and anti-HIV activity of Phyllanthus niruri whole plant extracts. Hexane, chloroform, ethyl acetate, acetone and methanol solvents were used to prepare the extracts by sequential maceration method. RetroSys HIV-1 RT (Innovagen, S...

Vitexin (1), isovitexin (2), orientin (3), isoorientin (4) and 1,3dihydroxy6, 7dimethoxyxanthone (5) were isolated from the whole plant of Begonia picta, a Nepalese crude drug commonly known as “Magarkaanche”. Structures were elucidated on the basis of chemical and spectroscopic methods. All of these compounds were isolated for the first time from B. picta and their in vitro antioxidant acti...