Withaferin A (Wit A), a steroidal lactone isolated from Withania somnifera, exhibits anti-inflammatory, immuno-modulatory and anti-angiogenic properties and antitumor activities. In the present study, we investigated the effects of Wit A on protease-mediated invasiveness of the human metastatic cancer cell lines Caski and SK-Hep1. We found that treatment with Wit A resulted in marked inhibition...

We conducted a large-scale screen for Drosophila mutants that have structural abnormalities of the larval neuromuscular junction (NMJ). We recovered mutations in wishful thinking (wit), a gene that positively regulates synaptic growth. wit encodes a BMP type II receptor. In wit mutant larvae, the size of the NMJs is greatly reduced relative to the size of the muscles. wit NMJs have reduced evok...

Eighteen Wilms' tumors (WIT), including classical triphasic WIT (blastema, tubules, and mesenchyme) and WIT variants (blastema and tubules, monomorphous tubules, multiloculated cysts, rhabdomyomatous WIT, and clear cell sarcoma), were heterotransplanted in nude mice. Ten (56%) tumors grew and were serially passaged. With two exceptions, the histology of the surgically resected tumors and hetero...

Eighteen Wilms' tumors (WIT), including classical triphasic WIT (blastema, tubules, and mesenchyme) and WIT variants (blas tema and tubules, monomorphous tubules, multiloculated cysts, rhabdomyomatous WIT, and clear cell sarcoma), were heterotransplanted in nude mice. Ten (56%) tumors grew and were serially passaged. With two exceptions, the histology of the surgically resected tumors and heter...

IMPORTANCE To our knowledge, this is a report of the first implantation of a wireless intraocular pressure transducer (WIT) in a human eye. OBJECTIVE To report preliminary safety data on the WIT. DESIGN, SETTING, AND PARTICIPANT In an institutional setting, a patient with open-angle glaucoma consented to be the recipient of the WIT in one eye in an interventional study design. INTERVENTIO...

Nine surgically resected Wilms' tumors (WIT) and nude mouse heterotransplants from one WIT were studied by histochemistry and immunohistochemistry. Histochemistry showed acid phosphatase in all cells, while alkaline phosphatase and gamma-glutamyl transpeptidase were present in only some tubules. Using immunohistochemistry, antibodies to the intermediate filaments cytokeratin and vimentin distin...

Although version spaces provide a useful conceptual tool for inductive concept learning, they often face severe computational difficulties when impls mented. For example, the G set of traditional boundary-set implementations of version spaces can have size exponential in the amount of data for even the most simple conjunctive description languages [Haussler, 19881. This paper presents a new rep...

Call-routing is now an established technology to automate customers’ telephone queries. However, transcribing calls for training purposes for a particular application requires considerable human effort, and it would be preferable for the system to learn routes without transcriptions being provided. This paper introduces a technique for fully automatic routing. It is based on firstly identifying...