Substance abuse is an important hygienic, psychic and social problem in the world. Gabapentin is a new antiepileptic drug that is used in neurological and psychiatric disorders. Moreover, the effects of gabapentin on increasing the analgesic effect of morphine and its inhibitory effect on dopamine release due to morphine in animal models have been proved. In the present study, the effect of gab...

Substance abuse is an important health, psychological and social problem in the world. Gabapentin is a new antiepileptic drug. It is used in neurological and psychiatric disorders. Moreover the effects of gabapentin on increasing the analgesic effect of morphine and its inhibitory effects on dopamine release due to morphine in animal models have been proved. In the present study, the effect of ...

Substance abuse is an important hygienic, psychic and social problem in the world. Gabapentin is a new antiepileptic drug that is used in neurological and psychiatric disorders. Moreover, the effects of gabapentin on increasing the analgesic effect of morphine and its inhibitory effect on dopamine release due to morphine in animal models have been proved. In the present study, the effect of gab...

Much research has focused on pathways leading to opiate addiction. Pathways opposing addiction are more difficult to study but may be critical in developing interventions to combat drug dependence and withdrawal. Galanin decreases firing of locus coeruleus neurons, an effect hypothesized to decrease signs of opiate withdrawal. The current study addresses whether galanin affects morphine withdra...

mice were rendered tolerant and dependent to morphine by subcutaneous injection of morphine over a period of 5 days. the effects of acute and chronic administration of dihydropyridine calcium channel antagonist nifedipine on the development of tolerance and naloxone-precipitated morphine withdrawal signs were investigated. a single injection of nifedipine proved to be effective in inhibiting so...

Introduction: This study was performed to evaluate the effects of intra-nucleus accumbens shell microinjection of Larginine (NO precursor) and L-NAME (nitric oxide synthase (NOS) inhibitor) on morphine withdrawal signs in male rats. Method: Rats were anaesthetized with a combination of ketamine and xylazine, and placed in stereotaxic apparatus, and a guide cannula was inserted into nucleus accu...

There is growing evidence indicating that neuronal calcium channels play an important role in the mechanism of morphine dependence. In this study, the effects of acute and chronic administration of nitrendipine on naloxone precipitated morphine withdrawal signs were investigated. Mice were rendered dependent to morphine by subcutaneous injection of morphine over a period of 5 days. In chronic s...

objective: addiction, especially morphine dependence is a prevalence and incurable disease. with regard to low ability of new chemical drugs in treatment of addicted ones and with respect to herbal medicine recommendation due to lower side effects and cheap production. this study experimentally examined the effect of p.harmala on morphine withdrawal syndrome. materials and methods: animals wer...