OBJECTIVE To determine the efficacy and safety of Curcuma domestica extracts in pain reduction and functional improvement. METHODS 367 primary knee osteoarthritis patients with a pain score of 5 or higher were randomized to receive ibuprofen 1,200 mg/day or C. domestica extracts 1,500 mg/day for 4 weeks. The main outcomes were Western Ontario and McMaster Universities Osteoarthritis Index (WO...

OBJECTIVE To evaluate the consistency of the questionnaires (WOMAC, Lequesne, VAS, SF 36-PCS and SF 36-MCS) when applied in patients with osteoarthritis of the knees (KOA) verifying if age and level of education interfere with the completion of the questionnaires. METHOD One hundred and two patients with KOA answered WOMAC, LESQUESNE, VAS and SF-36 questionnaires and provided data correlated ...

BACKGROUND The WOMAC (Western Ontario and McMaster Universities) function subscale is widely used in clinical trials of hip and knee osteoarthritis. Reducing the number of items of the subscale would enhance efficiency and compliance, particularly for use in clinical practice applications. OBJECTIVE To develop a short form of the WOMAC function subscale based on patients' and experts' opinion...

BACKGROUND The aim of this study was to assess the efficacy of choline-stabilized orthosilicic acid (ch-OSA) in patients with symptomatic knee osteoarthritis (OA). METHODS In a multicenter, double-blind, placebo-controlled study, 211 patients with knee OA (Kellgren and Lawrence grade II or III) and moderate to moderately severe pain were randomly allocated to ch-OSA or placebo for 12 weeks. T...

BACKGROUND The purpose of this study is to explore the relationship between function, pain and stiffness outcomes with individual and community socioeconomic status (SES) measures among individuals with radiographic knee osteoarthritis (rOA). METHODS Cross-sectional data from the Johnston County Osteoarthritis Project were analyzed for adults age 45 and older with knee rOA (n = 782) and a sub...

OBJECTIVE To investigate the factors associated with clinical progression and good prognosis in patients with lower limb osteoarthritis (OA). METHODS Cohort study of 145 patients with OA in either knee, hip or both. Progression was defined as 1) new joint prosthesis or 2) increase in WOMAC pain or function score during 6-years follow-up above pre-defined thresholds. Patients without progressi...

OBJECTIVE To measure the validity and reliability of the WOMAC, IKDC and Lysholm questionnaires among patients with knee osteoarthritis and determine the influence of age on their scores. METHOD Fifty-seven patients diagnosed with primary osteoarthritis of the knee answered the SF-36, WOMAC, IKDC and Lysholm questionnaires. Validity was tested by measuring the correlation (Pearson's correlati...

OBJECTIVE To develop a decision tree based on health-related quality of life outcomes rather than expert consensus for determining the appropriateness of total hip replacement (THR) among patients with hip OA. METHODS This is a prospective observational study of two independent cohorts. The derivation cohort included 590 patients recruited from seven hospitals between March 1999 and March 200...

PURPOSE To investigate the correlation between single limb support (SLS) phase (% of gait cycle) and the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) questionnaire and Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36 Health Survey) in patients with knee osteoarthritis (OA). METHOD A prospective observational study was employed with 125 adults with bilater...