In this study, we develop a framework for measuring the value of harmful algal bloom (HAB) predictions. The framework captures the effects of both private and public responses to HABs. Using data from the New England nearshore commercial shellfish fishery and impact estimates for a large-scale HAB event in 2005, we illustrate how the potential value of HAB forecasts may be estimated. The result...

Axon guidance is a key process during nervous system development and regeneration. One of the best established paradigms to study the mechanisms underlying this process is the axon decision of whether or not to cross the midline in the Drosophila CNS. An essential regulator of that decision is the well conserved Slit-Robo signaling pathway. Slit guidance cues act through Robo receptors to repel...

Drosophila Roundabout (Robo) is the founding member of a conserved family of repulsive axon guidance receptors that respond to secreted Slit proteins. Little is known about the signaling mechanisms which function downstream of Robo to mediate repulsion. Here, we present genetic and biochemical evidence that the Abelson (Abl) tyrosine kinase and its substrate Enabled (Ena) play direct and opposi...

First described as an axonal guidance cue through its repulsive effect on neurons expressing its receptor Roundabout (Robo), the Slit ligand has effects on cell migration, axon branching and elongation. Indirect evidence implicates Slit and Robo in lung development. We now demonstrate that Slit-2 and Slit-3 are developmentally regulated in embryonic murine lung. Immunohistochemistry demonstrate...

Department of General Surgery, County Health Centre in Kamienna Góra1 Kierownik: dr hab. M. Kruczek Department of Internal Diseases, County Health Centre in Kamienna Góra2 Kierownik: dr hab. r. grabowski Department of Dietetics, Chair of Gastroenterology and Hepatology, Medical University in Wrocław3 Kierownik: prof. dr hab. E. Poniewierka Department of Gastroenterology and Hepatology, Medical ...

Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is best known for mediating axon repulsion in the developing nervous system. However, in recent years the functional repertoire of Slits and Robo has expanded tremendously and Slit-Robo signaling has been linked to roles in neurogenesis, angiogenesis and cancer progression among other processes. Likewise, ...

Department of General, Vascular and Transplant Surgery, Warsaw Medical University1 Kierownik: prof. dr hab. J. szmidt Department of Hypertension, Institute of Cardiology in Warsaw2 Kierownik: prof. dr hab. a. Januszewicz II Department of Anesthesiology and Intensive Care, Warsaw Medical University3 Kierownik: prof. dr hab. a. kański Department of Endocrinology, Centre of Postgraduate Medical Ed...

In the Drosophila CNS, the midline repellent Slit acts at short range through its receptor Robo to control midline crossing. Longitudinal axons express high levels of Robo and avoid the midline; commissural axons that cross the midline express only low levels of Robo. Robo levels are in turn regulated by Comm. Here, we show that the Slit receptors Robo2 and Robo3 ensure the fidelity of this cro...

The robo gene in Drosophila was identified in a large-scale mutant screen for genes that control the decision by axons to cross the CNS midline. In robo mutants, too many axons cross and recross the midline. Here we show that robo encodes an axon guidance receptor that defines a novel subfamily of immunoglobulin superfamily proteins that is highly conserved from fruit flies to mammals. For thos...

1III Psychiatric Clinic, Institute of Psychiatry and Neurology in Warsaw Head: prof. dr hab. n. med. M. Jarema 2Department of Affective Disorders Chair of Psychiatry, Jagiellonian University Medical College Head: prof. dr hab. n. med. D. Dudek 3Department of Psychiatry Pomeranian Medical University, Szczecin Head: prof. dr hab. n. med. J. Samochowiec 4Department of Pharmacology, Institute of Ps...