BACKGROUND Oral therapies and chemodenervation procedures are often unrewarding in the treatment of focal, task-specific hand disorders such as writer's cramp or primary writing tremor (PWT). METHODS A portable writing orthotic device (WOD) was evaluated on 15 consecutively recruited writer's cramp and PWT subjects. We measured overall impairment at baseline and after 2 weeks of at-home use w...

Antimicrobial peptides have established an important role in the defense against extracellular infections, but the expression of cationic peptides within macrophages as an antibacterial effector mechanism against intracellular pathogens has not been demonstrated. Macrophage expression of the murine cathelicidin-related antimicrobial peptide (CRAMP) was increased after infection by the intracell...

Cathelicidins are a family of endogenous antimicrobial peptides that exert diverse immune functions, including both direct bacterial killing and immunomodulatory effects. In this study, we examined the contribution of the murine cathelicidin, cathelicidin-related antimicrobial peptide (CRAMP), to innate mucosal immunity in a mouse model of Gram-negative pneumonia. CRAMP expression is induced in...

BACKGROUND Night-time calf cramping affects approximately 1 in 3 adults. The aim of this study was to explore the experience of night-time calf cramp; if and where people seek treatment advice; and perceived treatment effectiveness. METHODS 80 adults who experienced night-time calf cramp at least once per week were recruited from the Hunter region, NSW, Australia through newspaper, radio and ...

Antimicrobial peptides are present in most living species and constitute important effector molecules of innate immunity. Recently, we and others have detected antimicrobial peptides in the brain. This is an organ that is rarely infected, which has mainly been ascribed to the protective functions of the blood-brain barrier (BBB) and meninges. Since the bactericidal properties of the BBB and men...

OBJECTIVE To determine whether there are diffusion abnormalities along the fibers connecting sensorimotor regions, including the primary sensorimotor areas and the striatum, in patients with writer's cramp using voxel-based diffusion analysis and fiber tracking. Recent studies have shown structural changes in these regions in writer's cramp. DESIGN Patient and control group comparison. SETT...

A new particle-based method, the material point method (MPM), has recently been extended to handle explicit cracks in a new algorithm called CRAMP or “CRAcks with Material Points.” This new method has several advantages for numerical work on fracture. Compared to finite element analysis, CRAMP can handle cracks with similar algorithmic efficiency, but is better at handling crack surface contact...

ABSTRACT Host-derived antimicrobial peptides play an important role in the defense against extracellular bacterial infections. However, capacity of derived from macrophages as potential antibacterial effectors intracellular pathogens remains unknown. In this study, we report that normal (wild-type, WT) mouse increased their expression cathelin-related peptide (CRAMP, encoded by Camp) after infe...

In an accompanying paper [2], we developed the Shorten [3] model of skeletal muscle by incorporating equations such as surface calcium fluxes. further research in this paper, succeeded reproducing cramp, well its prevention and reversal, investigating contraction which regulatory networks are involved, using extended comparison with original model. Incorporation data from a traditional medicine...

Ferguson, D. (1971). Brit. J. industr. Med., 28, 280-285. An Australian study of telegraphists' cramp. An investigation of telegraphists' cramp in an Australian public service organization attempted to assess the prevalance of the disorder, the degree of its transfer from morse to keyboard operating, and possible contributory influences. From an interview of 516 telegraphists in Sydney, Melbour...