The effect of xanthene dyes on the chemiluminescence from the aerobic indole-3-acetic acid (IAA) oxidation, catalyzed by horseradish peroxidase (HRP), was studied. The rate of IAA oxidation and dye destruction were controlled. It was found that the addition of dyes to the IAA/HRP/O2 system resulted in: (i) the appearance of emission in the region of dye fluorescence, (ii) an increase of the tot...

Two sensing molecules, A-T1 and A-T2 with bichromophore structures, were synthesized by linking different numbers of TPE units to a xanthene platform (ABPX).

The synthetic food dyes studied were rose bengal (RB), phroxine (PL), amaranth, erythrosine B (ET), allura red, new coccine, acid red (AR), tartrazine, sunset yellow FCF, brilliant blue FCF, and indigo carmine. First, data confirmed that these dyes were not substrates for CYP2A6, UGT1A6, and UGT2B7. ET inhibited UGT1A6 (glucuronidation of p-nitrophenol) and UGT2B7 (glucuronidation of androstero...

The title compound, C(35)H(38)N(4)O(3), was prepared as a spiro-lactam ring formation of rhodamine dye for comparison with a ring-opened form. The xanthene ring system is approximately planar. The dihedral angles formed by the spiro-lactam and phenol rings with the xanthene ring system are 85.7 and 109.4°, respectively. Each of the mol-ecules in the crystal structure contains one intra-molecula...

The catalytic effect of Zirconia Sulfuric Acid (ZrSA) nanoparticle which is synthesized from thereaction of ZrO with chlorosulfonic acid has been investigated in the synthesis oftetrahydrobenzo[a]xanthene-11-ones by one-pot three-component reaction of β-naphthol,aromatic aldehydes, and dimedone. Different reaction conditions were studied in the presence ofZrSA nanoparticle as catalyst. The resu...

The title compound, C(23)H(24)Cl(2)O(3), was synthesized by reaction of 2,4-dichloro-benzaldehyde and 5,5-dimethyl-cyclo-hexane-1,3-dione in ethyl-ene glycol. The central ring of the xanthene moiety is almost planar (with an r.m.s. deviation of 0.0268 Å from the least-squares plane) while the two outer rings, in a cis arrangement, display envelope conformations. The ring of the 2,4-dichloro-phe...

Chemical investigations of a microfungus Xylaria sp. isolated from the Australian rainforest tree Glochidion ferdinandi have afforded two new natural products, 2-hydroxy-6-methyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (1) and 2-hydroxy-6-hydroxymethyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (2). Compound 1 has previously been synthesised but only partially characterised. Methylatio...

Major advances in microscopy have revolutionized our view of the cell, allowing us to see what was previously not visible, now with unprecedented resolution. This would not be possible without an impressive portfolio of bright, modular, and photostable fluorescent dyes. Among these are xanthene-based dyes which includes fluorescein, a versatile FDA-approved reagent first synthesized more than a...

The title compound, C(31)H(20)N(2)O(5)·C(2)H(3)N, was synthesized by the reaction of fluorescein hydrazide and excess 2-hydr-oxy-1-naphthaldehyde in acetonitrile. The spirolactam ring is planar and is nearly at right angles to the two benzene rings of the xanthene system. The dihedral angle between the two benzene rings of the xanthene system is 9.92 (4)°. In the crystal structure, the mol-ecul...

The title compound, C(38)H(30)OP(2)S·CH(2)Cl(2), belongs to the xanthene family of ligands containing S- and O-donor atoms in the central heterocylic ring. Positions 2 and 8 on the xanthene backbone are functionalized with methyl groups to allow for the selective functionalization of the backbone at positions 4 and 6 with diphenyl-phosphanyl units. The title compound shows a significant 'roof-l...