practice and study of medicine in iran has a long and prolific history. iran has all characteristics of an indigenous culture which has so far discovered numerous natural products. unfortunately, scant research has been conducted on this system of medicine and ethnopharmacology of iran. gout is a historical disease that is still widespread all around the world. as numerous remedies used to be a...

The structure-activity relationship of flavonoids as inhibitors of xanthine oxidase and as scavengers of the superoxide radical, produced by the action of the enzyme xanthine oxidase, was investigated. The hydroxyl groups at C-5 and C-7 and the double bond between C-2 and C-3 were essential for a high inhibitory activity on xanthine oxidase. Flavones showed slightly higher inhibitory activity t...

Xanthine oxidase is a key enzyme which can catalyze hypoxanthine and xanthine to uric acid causing hyperuricemia in humans. Xanthine oxidase inhibitory activities of 24 organic extracts of four species belonging to Citrus genus of the family Rutaceae were assayed in vitro. Since the ethyl acetate extract of C. aurantium dried immature fruits showed the highest xanthine oxidase inhibitory activi...

To assay the in vitro xanthine oxidase and Tyrosinase inhibitory activity of the alkaloid fractions of the leaves of Indigofera spalathoides and to determine its enzyme inhibition mechanism. Xanthine oxidase and Tyrosinase inhibitory activity was assayed spectrophotometrically under aerobic conditions and the degree of enzyme inhibition was determined by measuring the increase in absorbance at ...

Fennel, Foeniculum vulgare Mill. (Apiaceae) is an aromatic plant, with medicinal and culinary applications, widely naturalized worldwide, especially near the see coasts and riversides. Fennel has long been used in Iran as a traditional remedy against gout. The objective of our study was to uncover the scientific basis of this traditional gout therapy. Different plant parts were extracted by met...

As the enzyme responsible for uric acid formation, Xanthine oxidase was considered to be a therapeutic target hyperuricemic treatment. This study carried out assess potential of caryophyllene, and its derivates usually present in natural product inhibit oxidase. The molecular docking using Autodock Tool Biovia Discovery Studio conducted visualize interaction reveal structure-activity relationsh...

Various dietary flavonoids were evaluated in vitro for their inhibitory effect on xanthine oxidase, which has been implicated in oxidative injury to tissue by ischemia-reperfusion. Xanthine oxidase activity was determined by directly measuring uric acid formation by HPLC. The structure-activity relationship revealed that the planar flavones and flavonols with a 7-hydroxyl group such as chrysin,...

Some medicinal plants from Papua have been used traditionally as hyperuricemia and antioxidant agents for many ethnic in Islands. The present study aims to evaluate inhibitory xanthine oxidase, antioxidative activities, total phenolic, flavonoid of five selected plants, Myrmecodia beccarii , Villebrunea rubescens Breynia cernua Bridelia spp. Dodonaea viscosa . Preliminary phytochemical screenin...

An attempt has been made to search for xanthine oxidase (XO) inhibitors from the root extracts of Tephrosia purpurea Linn. which is traditionally used in folk medicine in India. Root extracts were screened for in vitro antioxidant and xanthine oxidase inhibitory activity. Antioxidant activity was measured using ABTS, DPPH, FRAP and ORAC methods. The enzyme inhibitory activity was tested on puri...