Quetiapine fumarate, a first-line treatment for schizophrenia, exists in two formulations: extended release (XR) and immediate release (IR). This naturalistic, noninterventional study evaluated use of quetiapine XR/IR among in-patients with schizophrenia [ClinicalTrials.gov identifier: NCT01214135]. Data were collected from medical records. Categorical and numerical outcomes were compared using...

OBJECTIVES The atypical antipsychotic quetiapine is a first-line treatment for schizophrenia. This non-interventional study (NCT01212575) evaluated the clinical use of its two formulations, extended release (XR) and immediate release (IR), in outpatients with schizophrenia spectrum disorder. METHODS Patients who had received at least one dose of quetiapine XR and/or IR were included. A dosage...

Through improved adherence, once-monthly injectable extended-release naltrexone (XR-NTX) may provide an advantage over other oral agents approved for alcohol and opioid dependence treatment. The objective of this study was to evaluate cost and utilization outcomes between XR-NTX and other pharmacotherapies for treatment of alcohol and opioid dependence. Published studies were identified through...

Let XR be a geometrically irreducible smooth projective curve, defined over R, such that XR does not have any real points. Let X = XR×R C be the complex curve. We show that there is a universal real algebraic line bundle over XR × Pic d(XR) if and only if χ(L) is odd for L ∈ Picd(XR). There is a universal quaternionic algebraic line bundle over X × Pic(X) if and only if the degree d is odd. Tak...

Let XR be the zero locus in RP n of one or two independently and Weyl distributed random real quadratic forms. Denoting by XC the complex part in CP n of XR and by b(XR) and b(XC) the sums of their Betti numbers, we prove that: (1) lim n→∞ Eb(XR) n = 1. In particular for one quadric hypersurface asymptotically Smith’s inequality b(XR) ≤ b(XC) is expected to be sharp. The methods we use combine ...

The atypical antipsychotic quetiapine fumarate is available both as an immediate release (IR) and as an extended release (XR) formulation allowing flexibility of dosing for individual patients. Approved uses of quetiapine XR include the treatment of schizophrenia (including maintenance therapy for prevention of relapse), the treatment of bipolar disorder (manic and depressive episodes), and the...

OBJECTIVE We investigated low dose digital tomosynthesis (DT) for the evaluation of the paranasal sinus (PNS), and compared its diagnostic accuracy with a PNS radiography series (XR). MATERIALS AND METHODS We enrolled 43 patients for whom XR, PNS DT, and OMU CT were performed. We measured effective doses (EDs) of XR, DT, and OMU CT using Monte Carlo simulation software. Two radiologists perfo...

OBJECTIVE To compare 5mm slice computerized tomography (CT) and conventional x-ray (XR) in the detection of bone metastases in breast carcinoma patients. METHODS Ninety-eight female breast cancer patients treated in Ankara Oncology Hospital, Ankara, Turkey between September 1997 and March 2002 were assigned into 3 groups with respect to their Tc bone scan (Sc) results. Group 1 included patien...

BACKGROUND Duloxetine and venlafaxine extended release (venlafaxine XR) are SNRIs indicated for the treatment of MDD. This study addresses whether duloxetine and venlafaxine XR are interchangeable in their patterns of use with patients who are depressed or are used more selectively based on treatment history, background characteristics, and presenting symptoms. METHODS This was a retrospectiv...

The efficacy and tolerability of extended-release quetiapine fumarate (quetiapine XR) once-daily monotherapy in generalized anxiety disorder (GAD) was assessed. This multicentre, double-blind, randomized, placebo- and active-controlled, phase III trial consisted of a 1- to 4-wk enrolment/wash-out period and a 10-wk (8-wk active treatment, 2-wk post-treatment drug-discontinuation) study period; ...