A detailed parameterization is presented of a zinc ion with one histidine and two cysteinate ligands, together with one or two water, hydroxide, aldehyde, alcohol, or alkoxide ligands. The parameterization is tailored for the active site of alcohol dehydrogenase and is obtained entirely from quantum chemical computations. The force-field reproduces excellently the geometry of quantum chemically...

lead, copper, cobalt, nickel, iron and zinc ions form monocitrate complexes (negative charge) in citrate solution which is absorbed on the citrate form of anion-exchange resins (citrate as counter ion) y exchange of citrate ion with citrate complexes. these are subsequently recovered from the resin by 0.5m ammonium citrate eluent at ph 2.0. under optimized conditions, quantitative recovery was ...

X-ray studies on human insulins prepared by semisynthetic and biosynthetic methods have recently been undertaken. Human insulin differs from porcine insulin only at the COOH terminus of the B-chain. The present study reports the crystal structure of 4-zinc human insulin, which is used clinically as a slow-acting preparation. The structure has been refined, using 1.85-A resolution data, to a res...

Pure iron has been considered as a promising candidate for biodegradable implant applications. However, a faster degradation rate of pure iron is needed to meet the clinical requirement. In this work, metal vapor vacuum arc technology was adopted to implant zinc ions into the surface of pure iron. Results showed that the implantation depth of zinc ions was about 60 nm. The degradation rate of p...

The zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1) is inhibited by several classes of zinc-binders (sulfonamides, sulfamates, and sulfamides) as well as by compounds which do not interact with the metal ion (phenols, polyamines and coumarins). Here we report a new class of potent CA inhibitors which bind the zinc ion: the dithiocarbamates (DTCs). They coordinate to the zinc ion from the enzyme...

Lead, copper, cobalt, nickel, iron and zinc ions form monocitrate complexes (negative charge) in citrate solution which is absorbed on the citrate form of anion-exchange resins (citrate as counter ion) y exchange of citrate ion with citrate complexes. These are subsequently recovered from the resin by 0.5M ammonium citrate eluent at pH 2.0. Under optimized conditions, quantitative recovery ...

Metal ion homeostasis and heavy metal detoxification systems are regulated by certain genes associated with metal ion transport. Metallothionein (MT) and metal response element binding transcription factor 1 (MTF‑1) are important regulatory proteins involved in the mediation of intracellular metal ion balance. Differences in the zinc‑binding affinities of the zinc fingers of MTF‑1 and the α‑ an...

In this study, Response Surface Methodology (RSM) using Central Composite Design (CCD) was employed to optimize the conditions of independent variables (adsorption time and ion solution concentration) for the removal of Zinc (II) and Ag ions from the aqueous solutions using analcime and modified analcime zeolites (Fe-ANA and Ni-ANA) as efficient and low cost adsor...

The interaction of ribonuclease A with cupric and zinc ions has been studied spectrophotometrically and by potentiometric titration in the presence and absence of cytidylic acid derivatives. In the absence of cytidylic acid, the results suggest that each cupric ion distributes among a set of approximately four spectrally similar sites; each site appears to consist mainly of a single imidazole s...