background:childhood zinc deficiency is a common problem in many developing countries where people rely mainly on plant based diets with low zinc contents. zinc supplementation is one of strategies to combat zinc deficiency and its consequences in children. the aim of this community trial was to examine the effect of zinc supplementation on the linear growth of children 6-24 months of age and t...

objective: the present study was performed to compare the antioxidant effect of two different doses of zinc on lipid oxidation in type 2 diabetic patients. materials and methods: this double-blind, randomized controlled trial was conducted on 60 type 2 diabetic patients in yazd diabetes research center in 2008. the subjects were randomly allocated to receive zinc sulfate (iran, alhavi) either 2...

BACKGROUND For over a decade, the importance of zinc in the treatment of acute and persistent diarrhea has been recognized. In spite of recently published reviews, there remain several unanswered questions about the role of zinc supplementation in childhood diarrhea in the developing countries. Our study aimed to assess the therapeutic benefits of zinc supplementation in the treatment of acute ...

It is thought that zinc and selenium deficiency may play a significant role in the etiology of prostate cancer. Although joint zinc and selenium supplementation is frequently applied in the prevention of prostate diseases, the bioavailability of these elements in the prostate after co-administration is still unknown. The study examines the effect of subchronic supplementation of zinc gluconate an...

The age-related decline in lymphocyte development and function coincides with impaired zinc status in the elderly. Thymic involution and reduced immune responsiveness are classic hallmarks of both aging and zinc deficiency, resulting in decreased host defense and an increased susceptibility to infections. Thus, compromised zinc status associated with aging may be an important contributing facto...

OBJECTIVE to evaluate whether oral supplementation with zinc or zinc/arginine increases the antibody response to influenza vaccine or modulates the lymphocyte phenotype in elderly subjects. DESIGN a randomized controlled trial with two supplemented groups and one control group. SETTING a community nursing home. PARTICIPANTS 384 subjects aged 64-100 (mean age 82 years) examined in three se...

OBJECTIVE To assess the impact of zinc supplementation on nutritional and biochemical parameters among children aged 12 to 59 months. METHODS A blinded randomized clinical trial was carried out with 58 children aged 12 to 59 months included in the Programa Governamental de Combate a Carências Nutricionais (National Child Nutritional Program), which provided them with 2 kg of iron-fortified mi...

The metallothionein gene is transcriptionally regulated by zinc. Consequently, metallothionein has potential for serving as an index of dietary zinc status in humans. To examine this possibility, an enzyme-linked immunoassay (ELISA) based on a sandwich approach that utilizes monoclonal and chicken egg yolk antibodies was used to compare the response of erythrocyte metallothionein protein levels...

INTRODUCTION Zinc is an essential trace element for human nutrition, and its deficiency is associated with anorexia, poor food efficiency, growth retardation, and impaired neurological and immune systems. The zinc-deficiency rate is particularly high in many disease states, such as with end-stage renal disease patients undertaking hemodialysis. The aim of this study was to determine the effect ...