BACKGROUND The existing therapeutic methods for neonatal jaundice are costly, time-consuming and potentially risky. Zinc salts can reduce phototherapy duration by precipitating unconjugated bilirubin in the intestine (bilirubin and zinc can form a complex in physiologic pH); however, zinc toxicity is an issue that must be considered since theoretically bilirubin reduction by phototherapy may in...

The evaluation of the nutritional quality of foods and feeds requires a more definite knowledge of the physiological role of the various micro nutrient inorganic elements in the animal body than is now available. Problems of immediate concern include the effects of one or more of these elements on the utilization of another, for example the effect of traces of arsenic in reducing the toxicity o...

In dealing with zinc’s essentiality/toxicity (Dr. Jekyll and Mr. Hyde) duality, biological systems have developed the homeostatic ability to tightly regulate the zinc levels through a complicated framework for import and export, transport and distribution and sensing of zinc status to ensure that zinc does not participate in toxic reactions. In spite of the thousands of papers that have been pu...

Peroxynitrite toxicity has been implicated in the pathogenesis of white matter injury. The mechanisms of peroxynitrite toxicity to oligodendrocytes (OLs), the major cell type of the white matter, are unknown. Using primary cultures of mature OLs that express myelin basic protein, we found that 3-morpholinosydnonimine, a peroxynitrite generator, caused toxicity to OLs. N,N,N',N'-tetrakis (2-pyri...

Zinc plays many critical roles in biological systems: zinc bound to proteins has structural and catalytic functions, and zinc is proposed to act as a signaling molecule. Because zinc deficiency and excess result in toxicity, animals have evolved sophisticated mechanisms for zinc metabolism and homeostasis. However, these mechanisms remain poorly defined. To identify genes involved in zinc metab...

Diclofenac is a widely used analgesic drug that can cause serious adverse drug reactions. We used Saccharomyces cerevisiae as a model eukaryote with which to elucidate the molecular mechanisms of diclofenac toxicity and resistance. Although most yeast cells died during the initial diclofenac treatment, some survived and started growing again. Microarray analysis of the adapted cells identified ...

---There has been escalation in alcohol abuse with an enormous increase in alcohol-related gastrointestinal tract disorders. The study was conducted to evaluate the role of zinc on intestine of rats under ethanol toxicity. Rats were segregated into four groups: Control, Ethanol treated, Zinc treated and Combined zinc and ethanol treated. 1ml of 30% ethanol was given to rats orally everyday. Zin...

The composition of the intestinal lumen is likely to have considerable influence upon the absorption, and consequently the nutrition and/or toxicity, of ingested zinc in aquatic environments, where zinc is both a nutrient and a toxicant of importance. The effects of amino acids upon intestinal zinc uptake in freshwater rainbow trout (Oncorhynchus mykiss) were studied using an in vivo perfusion ...

1 Associate Professor, RMMCH 2 Post Graduate, RMMCH Abstract Background: Neonatal jaundice is one of the common newborn illness for which existing therapies are not only costly, time-consuming but also has some inherent risks. Phototherapy duration can be reduced by adding zinc salts. Uunconjugated bilirubin in the intestine (bilirubin and zinc can form a complex in physiologic pH) is precipita...