The leucine zipper (ZIP) motif consists of a periodic repetition of a leucine residue at every seventh position and forms an a-helical conformation, which facilitates dimerization and in some cases higher oligomerization of proteins. Inmany eukaryotic gene regulatory proteins, the ZIP motif is flanked at its N-terminus by a basic region containing characteristic residues that facilitate DNA bin...

Entrapment of prepuce in a zipper is a common cause of prepuceal injury in children. The reported interventions include dismantling the zipper with bone or wire cutters, to circumcision. A quick, simple and non-traumatic approach to the zipper manipulation is presented in which prepuce is instantly released by lateral compression of the zip fastener, using a pliers.

Multinucleated osteoclasts are responsible for bone resorption. Hypermultinucleated osteoclasts are often observed in some bone-related diseases such as Paget's disease and cherubism. The cellular mechanics controlling the size of osteoclasts is poorly understood. We introduced EGFP-actin into RAW 264.7 cells to monitor actin dynamics during osteoclast differentiation. Before their terminal dif...

The N-terminal region of the envelope (env) transmembrane protein of human immunodeficiency virus type 1 (HIV-1) has a leucine zipper-like motif. This highly conserved zipper motif, which consists of a heptad repeat of leucine or isoleucine residues, has been suggested to play a role in HIV-1 env glycoprotein oligomerization. This hypothesis was tested by replacing the highly conserved leucine ...

We explore which polyhedra and polyhedral complexes can be formed by folding up a planar polygonal region and fastening it with one zipper. We call the reverse process a zipper unfolding. A zipper unfolding of a polyhedron is a path cut that unfolds the polyhedron to a planar polygon; in the case of edge cuts, these are Hamiltonian unfoldings as introduced by Shephard in 1975. We show that all ...

The “zipper” data type provides the ability for editing tree shaped data in a pure functional setting and has found many uses and applications. However the traditional zipper has two major limitations. First, requires a significant amount of boilerplate code to implement. Second, it can only operate on homogeneous data types. Data structures where there are multiple node types are beyond the ra...

The design of highly wavelength tunable semiconductor laser structures is presented. The system is based on a one dimensional photonic crystal cavity consisting of two patterned, doubly-clamped nanobeams, otherwise known as a "zipper" cavity. Zipper cavities are highly dispersive with respect to the gap between nanobeams in which extremely strong radiation pressure forces exist. Schemes for con...