Although zinc oxide nanoparticles (ZnONPs) are recognized to cause systemic disorders, little is known about the mechanisms that underlie the time-dependent differences that occur after exposure. The objective of this study was to investigate the mechanistic differences at 24 hours and 28 days after the exposure of BALB/c mice to ZnONPs via intratracheal instillation. An isobaric tag for the re...

The work investigates the role of interfacial potential in defining antimicrobial propensity of ZnO nanoparticle (ZnONP) against different Gram positive and Gram negative bacteria. ZnONPs with positive and negative surface potential are tested against different bacteria with varying surface potentials, ranging -14.7 to -23.6 mV. Chemically synthesized ZnONPs with positive surface potential show...

Inflammatory bowel diseases (IBD) are widespread inflammatory diseases that cause debilitating health problems including cancer. In this study, we show that ZnO nanoparticle (ZnONP) treatment has markedly dose-dependent effects on the remission of dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. We demonstrate the mechanism involves the antioxidant and anti-inflammatory abilitie...

With the abundant production and wide application of zinc oxide nanoparticles (ZnONPs), potential health risks ZnONPs have raised serious concerns. Oxidative stress is recognized as most important outcome toxicity induced by ZnONPs. The Nrf2-Keap1 system its downstream antioxidative genes are fundamental protective mechanisms for redox hemeostasis. However, detailed Nrf2 activation in ZnONPs-tr...

The conventional electrodes like glassy carbon electrode and graphite are restricted for large-scale electrochemical production in-vivo applications. Therefore, flexible beginning to replace with such electrodes. This work reports a simple preparation of paper-like material (FPEM) including reduced graphene oxide (rGO) zinc nanoparticles (ZnONPs) possible For this purpose, dispersion was intera...

The use of nanoparticles in medicine is an attractive proposition. In the present study, zinc oxide and silver nanoparticles were evaluated for their antidiabetic activity. Fifty male albino rats with weight 120 ± 20 and age 6 months were used. Animals were grouped as follows: control; did not receive any type of treatment, diabetic; received a single intraperitoneal dose of streptozotocin (100...

Abstract This study evaluated the biological fabrication and characterization of zinc oxide nanoparticles (ZnONPs) using Nepeta cataria (NC) their anticancer activity against ovarian cancer cells (SKOV3). synthesized ZnONPs leaf extract N. through a method. The particles were characterized in several ways such as zeta potential, ultraviolet-visible (UV-Vis) spectrum, Fourier transform infrared ...

This study describes the use of banana peel (BPEs) and date seed extracts (DSEs) as waste products in sustainable eco-friendly biological synthesis zinc oxide nanoparticles (ZnONPs). ZnONPs_BPE ZnONPs_DSE were characterized using an ultraviolet-visible spectrophotometer (UV-VIS), Scanning (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), dynamic light scattering (DLS), zet...

Zinc is an essential mineral and accepted as a trace element in the animal nutrition and for its role in biological enzymatic pathways. This study aimed to investigate the effect of oral administration of zinc oxide nanoparticles (ZnONPs) on some of the antioxidant parameters of semen plasma, quantitative and qualitative properties of Arabic ram sperm in the non-breeding season. Twelve adult Ar...